1.0TBE Bookhttps://tbenews.com/tbeIThttps://tbenews.com/tbe/author/brianong/rich600338<blockquote class="wp-embedded-content" data-secret="l0Al8hw17h"><a href="https://tbenews.com/tbe/13-15-9/">Italy</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://tbenews.com/tbe/13-15-9/embed/#?secret=l0Al8hw17h" width="600" height="338" title="“Italy” — TBE Book" data-secret="l0Al8hw17h" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://tbenews.com/tbe/wp-includes/js/wp-embed.min.js </script> https://tbenews.com/tbe/wp-content/uploads/2017/07/Italy.jpg1180250TBE in Italy Valentina Tagliapietra, Martina Del Manso, Flavia Riccardo and Anna Teresa Palamara E-CDC risk status: endemic (last edited in June 2026, update for 2024: 48 reported cases; update for 2025: 63 reported cases) History and current situation Italy is considered a low-incidence country for tick-borne encephalitis (TBE) in Europe.1 Areas at higher risk for TBE within Italy are geographically clustered in the forested and mountainous regions and provinces of the northeastern part of the country, as suggested by TBE case series published over the last decade. 2–4 A national enhanced surveillance system for TBE has been established since 2017.5 Before this, information on the occurrence of TBE cases at the national level in Italy was lacking. Both incidence rates and the geographical distribution of the disease were mostly inferred from endemic areas where surveillance was already in place, and from ad hoc studies and international literature. TBE has been recorded in Italy since 1967, with foci of infections in the northeast (Trento, Belluno and Gorizia) and central (Florence and Latina) provinces.6–9 TBE presence in central Italy has not been confirmed by further studies on ticks and serosurveys conducted afterwards,10,11 nor by human cases, posing concerns about possible misdiagnosis. Serological investigations of people at risk, such as forestry rangers, hunters, hikers and forest products collectors, have been performed in order to get information on human exposure to TBE virus (TBEV). Circulation in the pre-alpine and alpine regions reported partially NT-confirmed seroprevalence values of 0.6%, 1.07% and 3.2% in Friuli-Venezia Giulia,12 Trento province13 and Turin province,14 respectively. Interestingly, Turin province has never reported TBE human cases, so far. A retrospective study conducted in 2015 in the northeast regions using the ECDC case definition of TBE,3 allowed the identification of 367 cases (0.38 per 100,000 inhabitants) during the period from 2000 to 2013.3 TBE cases were mainly males (70%) and the majority of them were between 30 and 70 years of age (see also Figure 2). A significant increase in the annual incidence rate (IR) was observed during the study period, from 0.18 per 100,000 in the year 2000 up to 0.59 per 100,000 in 2013 (95% confidence interval [CI]: 1.02–1.08, P>0.01).3 The majority of TBE cases occurred between April and October, consistent with the seasonal activity of ticks. According to this study, the risk of TBE is associated with altitude, with the highest values found for municipalities between 400 and 600 m a.s.l., and the IR falling along with municipality altitude decrease or increase.3 In 2022, TBE showed a record in the number of cases and mortality rates, with 72 cases, mainly from four northeastern Italian regions and provinces15: Trento (18 cases), Friuli-Venezia Giulia (12 cases) and Veneto (37 cases), and sporadically from other locations i.e. Emilia Romagna (2 cases), Liguria (2 cases) and Lazio (1 case) (Fig. 3) and 3 fatal events, resulting in an exceptionally high mortality rate of 4.17%. In its natural enzootic cycle, TBEV transmission involves ixodid ticks, mainly belonging to the genus Ixodes, and the small mammal hosts (rodents and insectivores) which support both ticks population and TBEV circulation. The link between tree masting, rodent population dynamics, density of nymphal ticks and eventually the incidence of tick-borne diseases in humans, has been investigated in several studies highlighting the expected two-year lag between a masting event and the increase in (infected) nymphs.16,17 In this context, a long-term study conducted in the Province of Trento positively correlated pollen data and TBE incidence in humans,18 therefore offering to public health agencies a potential early warning tool that might be used to plan preventive measures two years in advance. Of note is the fact that a huge mast event involving two important forest species (Fagus sylvatica and Picea abies) was recorded in 2020 and that the peak in the number of TBE cases happened in 2022. In particular, the province of Trento showed a sharp increase in TBE incidence since 2012, despite vaccination efforts. To assess the current risk of infection in the provincial territory, an integrated One-Health research approach was applied, combining the analysis of the distribution of human cases, the study of seroprevalence in sentinel hosts (goats) and the direct screening of questing ticks.19 A total of 1.56% of goats resulted positive for specific antibodies for TBEV. Sampling of ticks was concentrated in areas where TBEV circulation was observed both in seropositive goats or in humans, resulting in a prevalence of 0.17%. In particular these results revealed an increased prevalence of TBEV in ticks and the emergence of new active TBE foci which are located northward and at higher altitude (1.109 m a.s.l.) compared to previous investigations. None of the areas with seropositive goats was confirmed by TBEV detection in ticks and recent human cases, but this aspect needs further confirmation. Since the 1990s, rising cervid population numbers and changes in forest structure in the northeastern regions and provinces of Italy were observed in conjunction with an increase in TBE incidence,20 but this relationship is not always positive and at a threshold density level of ungulates, TBEV prevalence decreases.21 Transmission of TBEV from infected nymphs to co-feeding uninfected ticks on rodents is considered the most efficient route for the amplification of this virus, therefore, studies regarding the ecological and abiotic conditions affecting tick feeding dynamics are important. Recently a long-term longitudinal field study highlighted that the autumnal cooling rate and the presence of roe deer and mice are crucial ecological drivers for co-feeding transmission which in turn is reflected in the maintenance of a TBEV hotspot.22 The animal community composition and abundance are known to affect transmission of tick-borne diseases, suggesting that in highly diverse habitats TBE risk decreases. Using habitat richness as a proxy for vertebrate host diversity, high TBE risk corresponded to areas with intermediate richness. In endemic areas, such as those located in northeast Italy, TBE risk is higher probably because it features habitat types that are generally suitable for both ticks and hosts presence.23 Vaccination for TBE is currently recommended in Italy