1.0TBE Bookhttps://tbenews.com/tbeIThttps://tbenews.com/tbe/author/brianong/rich600338<blockquote class="wp-embedded-content" data-secret="G647VcGC3v"><a href="https://tbenews.com/tbe/13-21-9/">Moldova</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://tbenews.com/tbe/13-21-9/embed/#?secret=G647VcGC3v" width="600" height="338" title="“Moldova” — TBE Book" data-secret="G647VcGC3v" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://tbenews.com/tbe/wp-includes/js/wp-embed.min.js </script> https://tbenews.com/tbe/wp-content/uploads/2017/08/Moldova.jpg1180250TBE in Moldova Olga Sofronie, Olga Burduniuc, Greta Bălan ECDC risk status: affected (last edited in June 2026, update for 2024 and 2025: no cases) History and current situation Tick-borne encephalitis is monitored in the Republic of Moldova with an emphasis on surveillance of ticks with no attention to human cases. The competent national institution responsible for TBE monitoring is the National Agency for Public Health. Official data on vector testing have been recorded since 2011. Ever since, studies on the circulation of the TBEV are conducted annually in spring,  summer and autumn by collecting ticks from several regions of the country: Floreşti, Soroca, Bender, Tiraspol, Orhei, Drochia, Hînceşti, Ialoveni, Străşeni, Vadul lui Vodă, Chişinău, Taraclia, and Comrat territorial administrative units. TBEV was detected in most of the regions mentioned above, with highest isolation rates in Chişinău municipality (including Vadul lui Vodă), Străşeni, Comrat, Bender, and Tiraspol (Figure 1). Tick testing was carried out using commercial ELISA sets for the detection of TBEV antigen (VectoTBEV-antigen; Novosibirsk, Russian Federation; https://en.vector-best.ru/catalog/IFA/kits/tick-borne-and-zoonotic-infections/). Tick species most frequently encountered in the territory of the Republic of Moldova are Ixodes ricinus, Dermacentor marginatus, Dermacentor reticulatus, Haemaphysalis inermis and Haemapysalis punctata, while I. ricinus was present in all of the three geographical areas. The average density index of the species I. ricinus in the period 2009-2011 was ~21 at the standard 200 m route.1 In a study conducted in 2010-2011 the Far Eastern TBEV subtype was detected by PCR in ticks (I. ricinus, Dermacentor spp. and Haemaphysalis spp.) collected from vegetation and domestic animals in Moldova. The regions where the presence of the TBEV-FE subtype was confirmed were Chişinău municipality and Ungheni district.2 Generally speaking, commercial ELISA kits for detection of antibodies to the TBEV are available for use in patients with CNS symptoms and a history of a tick bite in Moldova.3 Studies on TBEV-seroprevalence in humans have not been carried out yet and testing for TBEV-infection is not routinely integrated into medical practice. During 2018 and 2023, a total of only 11 patient sera were tested for antibodies against the  TBEV. One was positive for anti-TBEV-IgM and one was positive for both, anti-TBEV-IgG and -IgM. The two patients were adults from different regions of the country (Făleşti, Tiraspol), and none of the two had a history of travel outside Moldova. In summary, the risk for TBEV-infection in Moldova has been confirmed by (1) the presence of the appropriate vectors – ixodid ticks in different territories of the Republic of Moldova – and (2) by the presence of ticks infected with the TBEV (Far Eastern subtype); as well as (3) by documentation of (some) human cases in the past. There is clearly a need to increase awareness of TBE in Moldova along with appropriate surveillance to better define the circulation of the TBEV in the country. Overview of TBE in Republic of Moldova Table 1: TBE in Moldova Viral subtypes isolated Far-Eastern subtype2 Reservoir animals Information not available Infected tick species (%) Dermacentor reticulatus 3,9% (3/77)2Ixodes ricinus 3,8% (3/78)2Haemaphysalis punctate 8,8% (3/34)2 Dairy product transmission Not documented Type of reporting Not mandatory Other TBE-surveillance Not applicable Special clinical features Monophasic (limited data)Risk groups (no data)Clinical manifestation (limited data) Licensed vaccines None Vaccination recommendations None Vaccine uptake Unknown National Reference center for TBE National Agency for Public Health, Chişinău, MD-2028, 67A Gh. Asachi st. /https://ansp.md/ Figure 1: Regions of Moldova with TBEV detection in ticks and location of 2 confirmed cases. Update for 2025: no data Note: (Ungheni, Străşeni, Comrat – district, Chişinău municipality, Bender, Tiraspol – towns)