{"version":"1.0","provider_name":"TBE Book","provider_url":"https:\/\/tbenews.com\/tbe","author_name":"IT","author_url":"https:\/\/tbenews.com\/tbe\/author\/brianong\/","title":"Japan - TBE Book","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"xrF7SGHfOK\"><a href=\"https:\/\/tbenews.com\/tbe\/13-16-9\/\">Japan<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/tbenews.com\/tbe\/13-16-9\/embed\/#?secret=xrF7SGHfOK\" width=\"600\" height=\"338\" title=\"&#8220;Japan&#8221; &#8212; TBE Book\" data-secret=\"xrF7SGHfOK\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/tbenews.com\/tbe\/wp-includes\/js\/wp-embed.min.js\n<\/script>\n","thumbnail_url":"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/02\/Japan.jpg","thumbnail_width":1180,"thumbnail_height":250,"description":"TBE in Japan Kentaro Yoshii E-CDC risk status: affected, possibly endemic (last edited in June 2026, update for 2024: 2 reported cases; update for 2025: 2 reported cases) History and current situation In Japan the Japanese encephalitis virus (JEV), one of mosquito-borne flaviviruses, has been widely endemic on the main and on the southern islands with more than 1,000 Japanese encephalitis (JE) cases reported annually in the late 1960s.1 In contrast, until 1993, no TBE case had ever been reported and it was considered that there was no endemic focus of TBEV. In 1993, a case of viral encephalitis in Hokuto city, in the southern part of Hokkaido, was diagnosed as TBE.2 The patient had suffered from fever, headache, and neurological symptoms such as seizures. Hemagglutination inhibition (HI) test against JEV showed significant increase in HI antibodies. However, 2-mercaptoethanol-sensitive HI antibodies were not detected, and it was unlikely that JEV infection occurred in Hokkaido, where JEV was not endemic. Furthermore, blood-sucking vector mosquitoes were not active at the end of autumn in the area. Further serological analysis was conducted against other flaviviruses. IgM-ELISA and neutralization tests revealed very low antibody titer against JEV while high titers of antibodies were detected by neutralization test against TBEV. Because the patient was a dairy farmer with no history of overseas travel, it was concluded that she had been infected with TBEV by a tick in her living area in Hokkaido. Epizootiological surveys were conducted in Hokkaido, antibodies against TBEV were detected in dogs, horses, racoons, deer and wild rodents in the wide areas of Hokkaido.3-12 TBEV was isolated from dogs, wild rodents and from Ixodes ovatus ticks, which are the predominant ticks in the area. Sequence and phylogenetic analysis classified the TBEV isolates as Far-Eastern subtype. Besides, antibodies against TBEV were detected in deer and wild rodents in the Tochigi, the Shimane and the Nagasaki prefectures, and antibodies against the TBEV-serocomplex were also detected in wild boars in wide areas of Japan (the Yamaguchi, Wakayama, Hyogo, Oita, Gifu, Toyama and Chiba prefecture), indicating wide distribution of TBEV all over Japan.4,11,13,14 Ever since the first confirmed TBE case in 1993, only four additional cases of TBE were reported from Japan, the last one in 2018, although endemic foci of TBEV were detected in various parts of the country, not only in Hokkaido. It is possible that TBE patients are missed in Japan. One major problem is the low awareness for the disease in Japan, even among physicians. Another problem is that commercial tests for diagnostic confirmation of TBEV-infections are not available due to low awareness and due to the restrictions to handle TBEV in high biosafety level laboratories (BSL 3) only. In Japan, no TBE vaccine is licensed, and it is an urgent medical need to conduct a serological survey among residents in TBEV-endemic areas and to establish preventive measures for residents as well as for travelers to Europe and Russia. Overview of TBE in Japan Only five confirmed cases of TBE have been reported from Japan to date. The first patient was a 37-year-old female in 1993,2,6 and the second patient was a male person in his 40s (2016).15 The third and fourth patients were male in their 70s (2017).16 The fifth patient was a female in her 40s (2018).17 Retrospective survey revealed infection with TBEV in one Lyme disease-suspected patient with meningoencephalitis18, seven patients with neurological disorders19 and two asymptomatic cases in Japan Self-Defense Forces members in Hokkaido.20 Other surveys also revealed infection with TBEV in three patients hospitalized with encephalitis or meningitis of unknown etiology outside Hokkaido.21 Table 1: TBE in Japan Viral subtypes, distribution Far-Eastern subtype5&#8211;9,12 Reservoir animals Wild rodents5,9,11 Infected tick species (%) I. ovatus\u00a0(0.05%\u20130.33%)7,8 Dairy product transmission Not reported Case definition used by authorities Isolation of TBEV or detection of TBEV genomic ribonucleic acid by RT-PCR from blood or cerebrospinal fluid; detection of IgM antibodies against TBEV from blood or cerebrospinal fluid; detection of significant increase in neutralizing antibodies against TBEV in paired serum.Based on the Infectious Diseases Control Law Type of reporting Mandatory Other TBE-surveillance Detection in ticks, wild and companion animals 3&#8211;13 Special clinical features Encephalitis and meningitis with typical neurological symptoms.6,15&#8211;17 Licensed vaccines FSME-Immun (2024) Vaccination recommendations No Vaccine uptake No National Reference center for TBE NATIONAL INSTITUTE OF INFECTIOUS DISEASE, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan, info@nih.go.jp Figure 1: Reported TBE cases in Japan 1993-2023.6,15-17 Update for 2025: 2 reported cases. Source data Figure 2: Age and gender distribution of TBE in Japan 1993-20236,15-17 Click the image above to enlarge Source data Figure 3: Geographic distribution of TBE in Japan4,5,8,11,13,15,16 Click the image above to enlarge Circles: Reported TBE cases 1993-2018 Red-colored prefecture: viral isolation, cases and TBEV-seropositive animals were reported Orange-colored prefectures: TBEV-seropositive animals were reported Contact Kentaro Yoshiikyoshii@nagasaki-u.ac.jp Author Kentaro Yoshii Citation Yoshii K. TBE in Japan. Chapter 13. In: Dobler G, Erber W, Br\u00f6ker M, Chitimia-Dobler L, Schmitt HJ, eds. The TBE Book. 9th ed. Singapore: Global Health Press; 2026. doi:10.33442\/26613980_13-16-9 References Arai S, Matsunaga Y, Takasaki T, et al. Japanese encephalitis: surveillance and elimination effort in Japan from 1982 to 2004. Jpn J Infect Dis. 2008;61(5):333-8. Morita K, Igarashi A, Sato T, Takezawa T. A suspected case of tick-borne encephalitis in Hokkaido. Vol. 15. 1994:273-4. Infect Agents Surv Rep. Hayasaka D, Suzuki Y, Kariwa H, et al. Phylogenetic and virulence analysis of tick-borne encephalitis viruses from Japan and far-Eastern Russia. J Gen Virol. 1999;80 ( Pt 12):3127-3135. doi:10.1099\/0022-1317-80-12-3127 Jamsransuren D, Yoshii K, Kariwa H, et al. Epidemiological survey of tick-borne encephalitis virus infection in wild animals on Hokkaido and Honshu islands, Japan. Japanese Journal of Veterinary Research. 2019;67(2):166-72. doi:10.14943\/jjvr.67.2.163 Kentaro Y, Yamazaki S, Mottate K, et al. Genetic and biological characterization of tick-borne encephalitis virus isolated from wild rodents in southern Hokkaido, Japan in 2008. Vector Borne Zoonotic Dis. 2013;13(6):406-14. doi:10.1089\/vbz.2012.1231 T Takashima I, Morita K, Chiba M, et al. A case of tick-borne encephalitis in Japan and isolation of the the virus. J Clin Microbiol. 1997;35(8):1943-1947. doi:10.1128\/jcm.35.8.1943-1947.1997 Takahashi"}