{"version":"1.0","provider_name":"TBE Book","provider_url":"https:\/\/tbenews.com\/tbe","author_name":"Administrator admin","author_url":"https:\/\/tbenews.com\/tbe\/author\/administrator-admin\/","title":"Denmark - TBE Book","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"Gm3GGfxDUK\"><a href=\"https:\/\/tbenews.com\/tbe\/tbe12b9\/\">Denmark<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/tbenews.com\/tbe\/tbe12b9\/embed\/#?secret=Gm3GGfxDUK\" width=\"600\" height=\"338\" title=\"&#8220;Denmark&#8221; &#8212; TBE Book\" data-secret=\"Gm3GGfxDUK\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/tbenews.com\/tbe\/wp-includes\/js\/wp-embed.min.js\n<\/script>\n","thumbnail_url":"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/01\/Denmark-1.jpg","thumbnail_width":1180,"thumbnail_height":250,"description":"TBE in Denmark Anders Fomsgaard E-CDC risk status: endemic (data as of end 2022) History and current situation Since the 1950s, tick-borne encephalitis (TBE) has been known to be endemic in Denmark but only on the island of Bornholm. Bornholm is situated east of mainland Denmark, south of Sweden (Figure 3) and has a different fauna and flora from the rest of Denmark. Bornholm has about 45,000 inhabitants, but about 500,000 tourists visit the island every year. Freundt carried out a serosurvey during 1958\u201319621 and found TBE antibodies in 1.4% of blood donors and 30% of woodworkers on Bornholm but no antibodies in subjects living in mainland Denmark. In 1963, Freundt found that 8 of 12 patients admitted to the hospital with acute meningoencephalitis of unknown etiology during 1951\u20131960 had antibodies to tick-borne encephalitis (TBEV).2 In 2000, TBE was rediscovered on Bornholm, where a retrospective study covering the period 1994\u20132002 (7 years) identified 14 TBE cases; 2 cases were tourists and 12 were inhabitants of Bornholm, giving an incidence of 3.81 per 100,000 inhabitants.3 At least 5 patients (37.7%) got permanent sequelae. In addition, 32 forest workers on Bornholm were tested in 2000, and 20% had IgG antibodies but never symptoms. This is similar to the finding of Freundt in 1960. It was concluded that the data did not provide evidence of an increase in incidence of TBE. Ticks (Ixodes ricinus) from Bornholm were investigated for TBEV in 2000 and 2% were found to be infected.4 Since 2001 an average of 2.5 (range 1\u20138) TBE cases per year have been reported in Bornholm (Figure 1). Figure 1: Burden of TBE in Denmark over time3,5,6 Click the image above to enlarge One of the TBE cases in 2008 and one in 2009 were infected in Tokkek\u00f8b microfocus;6 all others were infected on Bornholm Island, Denmark. According to the Danish legislation, TBE is not a notifiable disease. However, since the SSI in Copenhagen performs centralized diagnostic testing, a line-item list is compiled for laboratory confirmed cases (since 2001). Source data &#8211; In 2009, we succeeded in identifying a TBEV microfocus in a small forested area, Tokkek\u00f8b Hegn on Zealand just north of Copenhagen, which had a severe TBE case reported.6 A forest worker was infected in his backyard in Tokkek\u00f8b. The location is a small, open grass field bordering a lake and with a deer path. The patient had not been traveling. The patient described a similar case of encephalitis in 2008, when another man working in the forest kindergarten just 500m away from the forest worker got tick bites at the same spot. Both subjects had a typical biphasic disease and TBE was diagnosed.6 Both experienced persistent neurological sequelae, paralysis of one arm (both patients) and neuropsychiatric complications (one patient). TBEV European (Western) sub-type (TBEV-E) was identified in 2009 in I. ricinus tick adults and nymphs from the location identified by both patients (the &#8220;smoking gun principle&#8221;).6 In July and September 2011, TBEV-Eu was again identified (endemic) in adults and nymphs at Tokkek\u00f8b, and TBEV isolated (isolates T2 and T3). The virus sequence grouped with isolates from Sweden-Norway, whereas one Bornholm TBEV from 2012 grouped into a different subclade from South and Central Bohemia.7 A recent (2018) sequenced TBEV isolate from Bornholm (lake Rubins\u00f8en) grouped with TBEV from Switzerland and Finland.10 Whereas some TBEV microfoci may contain TBEV unchanged for decades (Finland), other foci in Denmark may merely provide permissive conditions for random and repeated TBEV introductions from various geographical locations. TBEV was not identified in 58 tick pools collected 2010\u20132011 in North Zealand, Fuen, and Jutland by flagging or from roe deer. In addition, 78 patients in North Zealand with &#8220;summer flu&#8221; after tick bites (July\u2013September 2010) and 96 hospitalized encephalitis patients after tick bites (2007\u20132009) who were negative for Borrelia all tested negative for TBE antibodies.7 This supports a limited TBEV introduction into the new microfocus. Serological testing of roe deer &#8220;sentinels&#8221;8 and computer predictions9 suggest TBEV outside Bornholm. But no other TBE cases have occurred in Denmark outside Bornholm from 2009-2017, and recent flaggings for ticks (September, October 2016 and June, July 2017) from the Tokkek\u00f8b microfocus were negative for TBEV.11 Yearly flaggings will continue, but we believe that the activity of the Tokkek\u00f8b microfocus has ended. All this changed by the hot summer in 2018 where 3 cases of TBE occurred, of which two were infected outside Bornholm: in Jutland (north of Esbjerg) and Fuen (near Faaborg), respectively. Moreover, the clinical manifestation of one of these was atypical, showing meningoradiculoneuritis rather than encephalitis.12 In June-July 2019 four cases (one case appeared during the publication of the three) were hospitalized, infected in the same wood area Tisvilde Hegn in Northern Zealand, bordering a playground. A new micro-focus was identified with a very high prevalence of 8% and only in nymphs. Whole genome sequencing showed clustering with a TBEV from Norway.13 In 2022, Denmark had 5 hospitalized cases of typical TBE diagnosed at Statens Serum Institut, 3 males and 2 females ranging between 31\u201373 years of age. Only one of the five cases was from Bornholm island and the rest were infected in North Zealand. Table 1: Virus, vector, transmission of TBE in Denmark Table 1: Virus, vector, transmission of TBE in Denmark Viral subtypes, distribution TBEV European (Western) subtype7 Reservoir animals Roe deer8 Infected tick species (%) 2%4 Dairy product transmission Not documented Table 2: TBE reporting and vaccine prevention in Denmark Mandatory TBE reporting TBE is not a notifiable disease in Denmark (DK) and there is no mandatory reporting Other TBE surveillance Statens Serum Institut (SSI) does the centralized TBE diagnostic in DK and compiles line-lists of confirmed cases Special clinical features Biphasic disease. Risk groups are people that regularly spend time in woods outside paths in areas where TBE is endemic (Bornholm)37.7% with permanent complications. No TBE deaths have been registered in Denmark3 Available vaccines Ticovac (Pfizer) Vaccination recommendations and reimbursement In 2001 the Danish Health Authorities recommended TBE vaccination for a defined at-risk population"}