{"id":10968,"date":"2019-01-14T11:32:45","date_gmt":"2019-01-14T03:32:45","guid":{"rendered":"https:\/\/id-ea.org\/tbe\/?p=10968"},"modified":"2019-05-14T18:07:16","modified_gmt":"2019-05-14T10:07:16","slug":"snapshot-week-3-2","status":"publish","type":"post","link":"https:\/\/tbenews.com\/tbe\/snapshot-week-3-2\/","title":{"rendered":"Snapshot 3\/2019<br> Severity of Lyme Borreliosis in elderly, Slovenia"},"content":{"rendered":"<span class=\"cb-itemprop\" itemprop=\"reviewBody\"><p>Bor\u0161i\u010d et al. Clinical course, serologic response, and long-term outcome in elderly patients with early Lyme Borreliosis.<br \/><em>J. Clin. Med<\/em>. 2018, 7, 506; doi:10.3390\/jcm7120506<\/p>\n<p>For TBE, it is well known that older patients suffer from more severe clinical symptoms and have more adverse outcomes than younger patients.<\/p>\n<p>For other tick-borne diseases, less is known on the association between patient age and severity of disease and recovery, e.g. Lyme disease (LD). In Slovenia, more than 1220 patients with erythema migrans (EM) were enrolled in clinical studies from 2006 to 2015 and were treated with appropriate antibiotics and treatment guidelines (doxycycline, cefuroxime axetil, amoxicillin or ceftriaxone) and were categorized as young (18 to 44 years), middle-aged (45 to 64 years) or elderly (\u226565 years). The long-term outcome of EM was excellent in patients of all age groups. The large majority (\u226583%) of patients in all age groups showed complete response from two months onward, returning to their pre-LD health status and treatment failure was documented in only 1.1%. However, the time to resolution of EM after starting antibiotic treatment showed significant prolongation with advancing age, which accords with delayed response to therapy in elderly patients with other types of infection, such as pneumonia. Older patients also had higher odds for an unfavorable outcome of treatment for middle-aged vs. young and for elderly vs. young, predominantly manifested as post-LB symptoms. The results presented here may be applicable to other European countries with similar ratios of <em>Borrelia<\/em> genospecies causing EM, but may not entirely apply to North America, where LD is caused nearly exclusively by B. <em>burgdorferi<\/em> sensu stricto (instead of <em>B. afzelii<\/em>).<\/p>\n<\/span>","protected":false},"excerpt":{"rendered":"<p>Bor\u0161i\u010d et al. Clinical course, serologic response, and long-term outcome in elderly patients with early Lyme Borreliosis.J. Clin. Med. 2018, 7, 506; doi:10.3390\/jcm7120506 For TBE, it is well known that older patients suffer from more severe clinical symptoms and have more adverse outcomes than younger patients. For other tick-borne diseases, less is known on the association between patient age and severity of disease and recovery, e.g. Lyme disease (LD). In Slovenia, more than 1220 patients with erythema migrans (EM) were enrolled in clinical studies from 2006 to 2015 and were treated with appropriate antibiotics and treatment guidelines (doxycycline, cefuroxime axetil, amoxicillin or ceftriaxone) and were categorized as young (18 to 44 years), middle-aged (45 to 64 years) or elderly (\u226565 years). The long-term outcome of EM was excellent in patients of all age groups. The large majority (\u226583%) of patients in all age groups showed complete response from two months onward, returning to their pre-LD health status and treatment failure was documented in only 1.1%. However, the time to resolution of EM after starting antibiotic treatment showed significant prolongation with advancing age, which accords with delayed response to therapy in elderly patients with other types of infection, such as pneumonia. Older patients also had higher odds for an unfavorable outcome of treatment for middle-aged vs. young and for elderly vs. young, predominantly manifested as post-LB symptoms. The results presented here may be applicable to other European countries with similar ratios of Borrelia genospecies causing EM, but may not entirely apply to North America, where LD is caused nearly exclusively by B. burgdorferi sensu stricto (instead of B. afzelii).<\/p>\n","protected":false},"author":6,"featured_media":12864,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[156,18],"tags":[58,59,57],"coauthors":[81],"class_list":["post-10968","post","type-post","status-publish","format-standard","has-post-thumbnail","category-jan-2019-snapshot","category-snapshot","tag-borrelia-burgdorferi","tag-borreliosis","tag-lyme-disease"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Snapshot 3\/2019 Severity of Lyme Borreliosis in elderly, Slovenia - TBE Book<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tbenews.com\/tbe\/snapshot-week-3-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Snapshot 3\/2019 Severity of Lyme Borreliosis in elderly, Slovenia - TBE Book\" \/>\n<meta property=\"og:description\" content=\"Bor\u0161i\u010d et al. Clinical course, serologic response, and long-term outcome in elderly patients with early Lyme Borreliosis.J. Clin. Med. 2018, 7, 506; doi:10.3390\/jcm7120506 For TBE, it is well known that older patients suffer from more severe clinical symptoms and have more adverse outcomes than younger patients. For other tick-borne diseases, less is known on the association between patient age and severity of disease and recovery, e.g. Lyme disease (LD). In Slovenia, more than 1220 patients with erythema migrans (EM) were enrolled in clinical studies from 2006 to 2015 and were treated with appropriate antibiotics and treatment guidelines (doxycycline, cefuroxime axetil, amoxicillin or ceftriaxone) and were categorized as young (18 to 44 years), middle-aged (45 to 64 years) or elderly (\u226565 years). The long-term outcome of EM was excellent in patients of all age groups. The large majority (\u226583%) of patients in all age groups showed complete response from two months onward, returning to their pre-LD health status and treatment failure was documented in only 1.1%. However, the time to resolution of EM after starting antibiotic treatment showed significant prolongation with advancing age, which accords with delayed response to therapy in elderly patients with other types of infection, such as pneumonia. Older patients also had higher odds for an unfavorable outcome of treatment for middle-aged vs. young and for elderly vs. young, predominantly manifested as post-LB symptoms. The results presented here may be applicable to other European countries with similar ratios of Borrelia genospecies causing EM, but may not entirely apply to North America, where LD is caused nearly exclusively by B. burgdorferi sensu stricto (instead of B. afzelii).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/tbenews.com\/tbe\/snapshot-week-3-2\/\" \/>\n<meta property=\"og:site_name\" content=\"TBE Book\" \/>\n<meta property=\"article:published_time\" content=\"2019-01-14T03:32:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-05-14T10:07:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/11\/TBE-Snapshots.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1180\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Michael Br\u00f6ker\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Michael Br\u00f6ker\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-3-2\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-3-2\\\/\"},\"author\":{\"name\":\"augustine\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#\\\/schema\\\/person\\\/2f903afeb7534df7457d2e3f6d30f64c\"},\"headline\":\"Snapshot 3\\\/2019 Severity of Lyme Borreliosis in elderly, Slovenia\",\"datePublished\":\"2019-01-14T03:32:45+00:00\",\"dateModified\":\"2019-05-14T10:07:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-3-2\\\/\"},\"wordCount\":267,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-3-2\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/wp-content\\\/uploads\\\/2017\\\/11\\\/TBE-Snapshots.jpg\",\"keywords\":[\"Borrelia burgdorferi\",\"borreliosis\",\"Lyme Disease\"],\"articleSection\":[\"Jan 2019 Snapshot\",\"Snapshot\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-3-2\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-3-2\\\/\",\"url\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-3-2\\\/\",\"name\":\"Snapshot 3\\\/2019 Severity of Lyme Borreliosis in elderly, Slovenia - 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Clinical course, serologic response, and long-term outcome in elderly patients with early Lyme Borreliosis.J. Clin. Med. 2018, 7, 506; doi:10.3390\/jcm7120506 For TBE, it is well known that older patients suffer from more severe clinical symptoms and have more adverse outcomes than younger patients. For other tick-borne diseases, less is known on the association between patient age and severity of disease and recovery, e.g. Lyme disease (LD). In Slovenia, more than 1220 patients with erythema migrans (EM) were enrolled in clinical studies from 2006 to 2015 and were treated with appropriate antibiotics and treatment guidelines (doxycycline, cefuroxime axetil, amoxicillin or ceftriaxone) and were categorized as young (18 to 44 years), middle-aged (45 to 64 years) or elderly (\u226565 years). The long-term outcome of EM was excellent in patients of all age groups. The large majority (\u226583%) of patients in all age groups showed complete response from two months onward, returning to their pre-LD health status and treatment failure was documented in only 1.1%. However, the time to resolution of EM after starting antibiotic treatment showed significant prolongation with advancing age, which accords with delayed response to therapy in elderly patients with other types of infection, such as pneumonia. Older patients also had higher odds for an unfavorable outcome of treatment for middle-aged vs. young and for elderly vs. young, predominantly manifested as post-LB symptoms. The results presented here may be applicable to other European countries with similar ratios of Borrelia genospecies causing EM, but may not entirely apply to North America, where LD is caused nearly exclusively by B. burgdorferi sensu stricto (instead of B. afzelii).","og_url":"https:\/\/tbenews.com\/tbe\/snapshot-week-3-2\/","og_site_name":"TBE Book","article_published_time":"2019-01-14T03:32:45+00:00","article_modified_time":"2019-05-14T10:07:16+00:00","og_image":[{"width":1180,"height":250,"url":"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/11\/TBE-Snapshots.jpg","type":"image\/jpeg"}],"author":"Michael Br\u00f6ker","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Michael Br\u00f6ker","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/tbenews.com\/tbe\/snapshot-week-3-2\/#article","isPartOf":{"@id":"https:\/\/tbenews.com\/tbe\/snapshot-week-3-2\/"},"author":{"name":"augustine","@id":"https:\/\/tbenews.com\/tbe\/#\/schema\/person\/2f903afeb7534df7457d2e3f6d30f64c"},"headline":"Snapshot 3\/2019 Severity of Lyme Borreliosis in elderly, Slovenia","datePublished":"2019-01-14T03:32:45+00:00","dateModified":"2019-05-14T10:07:16+00:00","mainEntityOfPage":{"@id":"https:\/\/tbenews.com\/tbe\/snapshot-week-3-2\/"},"wordCount":267,"commentCount":0,"publisher":{"@id":"https:\/\/tbenews.com\/tbe\/#organization"},"image":{"@id":"https:\/\/tbenews.com\/tbe\/snapshot-week-3-2\/#primaryimage"},"thumbnailUrl":"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/11\/TBE-Snapshots.jpg","keywords":["Borrelia burgdorferi","borreliosis","Lyme Disease"],"articleSection":["Jan 2019 Snapshot","Snapshot"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/tbenews.com\/tbe\/snapshot-week-3-2\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/tbenews.com\/tbe\/snapshot-week-3-2\/","url":"https:\/\/tbenews.com\/tbe\/snapshot-week-3-2\/","name":"Snapshot 3\/2019 Severity of Lyme Borreliosis in elderly, Slovenia - 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