{"id":13228,"date":"2019-05-14T19:32:15","date_gmt":"2019-05-14T11:32:15","guid":{"rendered":"https:\/\/id-ea.org\/tbe\/v2\/?p=13228"},"modified":"2019-05-29T15:00:32","modified_gmt":"2019-05-29T07:00:32","slug":"snapshot-week-19-2019-the-alpha-gal-syndrome-a-phenomenon","status":"publish","type":"post","link":"https:\/\/tbenews.com\/tbe\/snapshot-week-19-2019-the-alpha-gal-syndrome-a-phenomenon\/","title":{"rendered":"Snapshot week 19\/2019<br> &#8211; The alpha Gal syndrome: a phenomenon"},"content":{"rendered":"<span class=\"cb-itemprop\" itemprop=\"reviewBody\"><p>de la Fuente et al.<br \/>\nThe alpha-Gal syndrome: new insights into the tick-host conflict and cooperation<br \/>\nParasit. Vectors 2019, 12:154, doi.org\/10.1186\/s13071-019-3413-z<\/p>\n<p>Many animals, including mammals, amphibians, mollusks, as well as ticks consist of the enzyme \u03b1 -1-3- galactosyltransferase and can synthesize the galactose-based oligosaccharide Gal \u03b1 1-3Gal \u03b2 1-(3)4GlcNAc-R (Gal) (\u03b1 Gal). However, humans (like birds and fish) cannot produce \u03b1 Gal and therefore, \u03b1 Gal can trigger an immune response, as well as IgE antibodies and an allergic disease \u2013 the alpha Gal syndrome. Ticks bites can induce high levels of anti \u03b1Gal IgG antibodies that mediate delayed anaphylaxis to red meat consumption, and immediate anaphylaxis to tick bites, xenotransplantation and certain drugs such as cetuximab. The alpha-Gal syndrome is becoming a global problem. Most patients that had become allergic, had tolerated red meat for many years before being sensitized by tick bites. While in the past, the negative effects of the \u03b1 Gal immune response was in focus, the authors discuss here possible benefits of the \u03b1 Gal immune response. The anti \u03b1 Gal immune response may help protect against certain pathogens, e.g. <em>Mycobacterium, Trypanosoma, Borrelia, Leishmania<\/em>.<\/p>\n<p>In this context, vaccines may be developed against pathogens carrying \u03b1 Gal epitopes and recently, it could be shown that e.g. an \u03b1 Gal based glycovaccine can protect against the murine acute Chagas disease (Portillo et al. npj Vaccines 2019, 4:13).<\/p>\n<\/span>","protected":false},"excerpt":{"rendered":"<p>de la Fuente et al. The alpha-Gal syndrome: new insights into the tick-host conflict and cooperation Parasit. Vectors 2019, 12:154, doi.org\/10.1186\/s13071-019-3413-z Many animals, including mammals, amphibians, mollusks, as well as ticks consist of the enzyme \u03b1 -1-3- galactosyltransferase and can synthesize the galactose-based oligosaccharide Gal \u03b1 1-3Gal \u03b2 1-(3)4GlcNAc-R (Gal) (\u03b1 Gal). However, humans (like birds and fish) cannot produce \u03b1 Gal and therefore, \u03b1 Gal can trigger an immune response, as well as IgE antibodies and an allergic disease \u2013 the alpha Gal syndrome. Ticks bites can induce high levels of anti \u03b1Gal IgG antibodies that mediate delayed anaphylaxis to red meat consumption, and immediate anaphylaxis to tick bites, xenotransplantation and certain drugs such as cetuximab. The alpha-Gal syndrome is becoming a global problem. Most patients that had become allergic, had tolerated red meat for many years before being sensitized by tick bites. While in the past, the negative effects of the \u03b1 Gal immune response was in focus, the authors discuss here possible benefits of the \u03b1 Gal immune response. The anti \u03b1 Gal immune response may help protect against certain pathogens, e.g. Mycobacterium, Trypanosoma, Borrelia, Leishmania. In this context, vaccines may be developed against pathogens carrying \u03b1 Gal epitopes and recently, it could be shown that e.g. an \u03b1 Gal based glycovaccine can protect against the murine acute Chagas disease (Portillo et al. npj Vaccines 2019, 4:13).<\/p>\n","protected":false},"author":6,"featured_media":12864,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[18],"tags":[247,246,248,250,249],"coauthors":[81],"class_list":["post-13228","post","type-post","status-publish","format-standard","has-post-thumbnail","category-snapshot","tag-allergy","tag-alpha-gal-syndrome","tag-immunoglobulin-e","tag-red-meat","tag-vaccine"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Snapshot week 19\/2019 - The alpha Gal syndrome: a phenomenon - TBE Book<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tbenews.com\/tbe\/snapshot-week-19-2019-the-alpha-gal-syndrome-a-phenomenon\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Snapshot week 19\/2019 - The alpha Gal syndrome: a phenomenon - TBE Book\" \/>\n<meta property=\"og:description\" content=\"de la Fuente et al. The alpha-Gal syndrome: new insights into the tick-host conflict and cooperation Parasit. Vectors 2019, 12:154, doi.org\/10.1186\/s13071-019-3413-z Many animals, including mammals, amphibians, mollusks, as well as ticks consist of the enzyme \u03b1 -1-3- galactosyltransferase and can synthesize the galactose-based oligosaccharide Gal \u03b1 1-3Gal \u03b2 1-(3)4GlcNAc-R (Gal) (\u03b1 Gal). However, humans (like birds and fish) cannot produce \u03b1 Gal and therefore, \u03b1 Gal can trigger an immune response, as well as IgE antibodies and an allergic disease \u2013 the alpha Gal syndrome. Ticks bites can induce high levels of anti \u03b1Gal IgG antibodies that mediate delayed anaphylaxis to red meat consumption, and immediate anaphylaxis to tick bites, xenotransplantation and certain drugs such as cetuximab. The alpha-Gal syndrome is becoming a global problem. Most patients that had become allergic, had tolerated red meat for many years before being sensitized by tick bites. While in the past, the negative effects of the \u03b1 Gal immune response was in focus, the authors discuss here possible benefits of the \u03b1 Gal immune response. The anti \u03b1 Gal immune response may help protect against certain pathogens, e.g. Mycobacterium, Trypanosoma, Borrelia, Leishmania. In this context, vaccines may be developed against pathogens carrying \u03b1 Gal epitopes and recently, it could be shown that e.g. an \u03b1 Gal based glycovaccine can protect against the murine acute Chagas disease (Portillo et al. npj Vaccines 2019, 4:13).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/tbenews.com\/tbe\/snapshot-week-19-2019-the-alpha-gal-syndrome-a-phenomenon\/\" \/>\n<meta property=\"og:site_name\" content=\"TBE Book\" \/>\n<meta property=\"article:published_time\" content=\"2019-05-14T11:32:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-05-29T07:00:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/11\/TBE-Snapshots.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1180\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Michael Br\u00f6ker\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Michael Br\u00f6ker\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-19-2019-the-alpha-gal-syndrome-a-phenomenon\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-19-2019-the-alpha-gal-syndrome-a-phenomenon\\\/\"},\"author\":{\"name\":\"augustine\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#\\\/schema\\\/person\\\/2f903afeb7534df7457d2e3f6d30f64c\"},\"headline\":\"Snapshot week 19\\\/2019 &#8211; 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The alpha-Gal syndrome: new insights into the tick-host conflict and cooperation Parasit. Vectors 2019, 12:154, doi.org\/10.1186\/s13071-019-3413-z Many animals, including mammals, amphibians, mollusks, as well as ticks consist of the enzyme \u03b1 -1-3- galactosyltransferase and can synthesize the galactose-based oligosaccharide Gal \u03b1 1-3Gal \u03b2 1-(3)4GlcNAc-R (Gal) (\u03b1 Gal). However, humans (like birds and fish) cannot produce \u03b1 Gal and therefore, \u03b1 Gal can trigger an immune response, as well as IgE antibodies and an allergic disease \u2013 the alpha Gal syndrome. Ticks bites can induce high levels of anti \u03b1Gal IgG antibodies that mediate delayed anaphylaxis to red meat consumption, and immediate anaphylaxis to tick bites, xenotransplantation and certain drugs such as cetuximab. The alpha-Gal syndrome is becoming a global problem. Most patients that had become allergic, had tolerated red meat for many years before being sensitized by tick bites. While in the past, the negative effects of the \u03b1 Gal immune response was in focus, the authors discuss here possible benefits of the \u03b1 Gal immune response. The anti \u03b1 Gal immune response may help protect against certain pathogens, e.g. Mycobacterium, Trypanosoma, Borrelia, Leishmania. In this context, vaccines may be developed against pathogens carrying \u03b1 Gal epitopes and recently, it could be shown that e.g. an \u03b1 Gal based glycovaccine can protect against the murine acute Chagas disease (Portillo et al. npj Vaccines 2019, 4:13).","og_url":"https:\/\/tbenews.com\/tbe\/snapshot-week-19-2019-the-alpha-gal-syndrome-a-phenomenon\/","og_site_name":"TBE Book","article_published_time":"2019-05-14T11:32:15+00:00","article_modified_time":"2019-05-29T07:00:32+00:00","og_image":[{"width":1180,"height":250,"url":"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/11\/TBE-Snapshots.jpg","type":"image\/jpeg"}],"author":"Michael Br\u00f6ker","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Michael Br\u00f6ker","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/tbenews.com\/tbe\/snapshot-week-19-2019-the-alpha-gal-syndrome-a-phenomenon\/#article","isPartOf":{"@id":"https:\/\/tbenews.com\/tbe\/snapshot-week-19-2019-the-alpha-gal-syndrome-a-phenomenon\/"},"author":{"name":"augustine","@id":"https:\/\/tbenews.com\/tbe\/#\/schema\/person\/2f903afeb7534df7457d2e3f6d30f64c"},"headline":"Snapshot week 19\/2019 &#8211; 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