{"id":13726,"date":"2019-06-04T16:48:38","date_gmt":"2019-06-04T08:48:38","guid":{"rendered":"https:\/\/id-ea.org\/tbe\/?p=13726"},"modified":"2019-07-08T15:10:52","modified_gmt":"2019-07-08T07:10:52","slug":"snapshot-week-23-2019-post-exposure-treatment-of-tbe","status":"publish","type":"post","link":"https:\/\/tbenews.com\/tbe\/snapshot-week-23-2019-post-exposure-treatment-of-tbe\/","title":{"rendered":"Snapshot week 23\/2019<br> Post-exposure treatment of TBE"},"content":{"rendered":"<span class=\"cb-itemprop\" itemprop=\"reviewBody\"><p>Matveev et al.<br \/>\nPost-exposure administration of chimeric antibody protects mice against European, Siberian, and Far-Eastern subtypes of tick-borne encephalitis virus<br \/>\nPLoS ONE 14 (4): e0215075<\/p>\n<p>In most countries, exposure treatment of a TBE infection by immunoglobulin (Ig) preparations is not permitted. The production of Ig preparations has been suspended due to concerns regarding a possible enhancement (antibody dependent enhancement, ADE) of TBE after its administration, e.g. by non-neutralizing TBE antibodies and\/or too low antibody concentrations. However, in Russia the use of TBE Ig preparations is still in use. As an alternative to the use of these preparations for therapeutic treatment, a chimeric monoclonal antibody (chFVN145) which binds to epitopes in the DIII region of glycoprotein E, was been evaluated. Post-exposure treatment of mice with 100 \u03bcg or10 \u03bcg chFVN145 one day after infection with 159 LD<sub>50<\/sub> TBE-Eu virus protected mice in 100% or 50%, respectively. Similar results were obtained using TBE virus subtypes Sib and FE and when treatment was started at day 2 or 3 post infection. Treatment with non-protective doses did not indicate any ADE independent of the subtypes used for infection. These results indicate that chFVN145 would be of value in designing potential anti-TBE preparations.<\/p>\n<\/span>","protected":false},"excerpt":{"rendered":"<p>Matveev et al. Post-exposure administration of chimeric antibody protects mice against European, Siberian, and Far-Eastern subtypes of tick-borne encephalitis virus PLoS ONE 14 (4): e0215075 In most countries, exposure treatment of a TBE infection by immunoglobulin (Ig) preparations is not permitted. The production of Ig preparations has been suspended due to concerns regarding a possible enhancement (antibody dependent enhancement, ADE) of TBE after its administration, e.g. by non-neutralizing TBE antibodies and\/or too low antibody concentrations. However, in Russia the use of TBE Ig preparations is still in use. As an alternative to the use of these preparations for therapeutic treatment, a chimeric monoclonal antibody (chFVN145) which binds to epitopes in the DIII region of glycoprotein E, was been evaluated. Post-exposure treatment of mice with 100 \u03bcg or10 \u03bcg chFVN145 one day after infection with 159 LD50 TBE-Eu virus protected mice in 100% or 50%, respectively. Similar results were obtained using TBE virus subtypes Sib and FE and when treatment was started at day 2 or 3 post infection. Treatment with non-protective doses did not indicate any ADE independent of the subtypes used for infection. These results indicate that chFVN145 would be of value in designing potential anti-TBE preparations.<\/p>\n","protected":false},"author":6,"featured_media":12864,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[18],"tags":[270,267,264,268,269],"coauthors":[81],"class_list":["post-13726","post","type-post","status-publish","format-standard","has-post-thumbnail","category-snapshot","tag-antibody-dependent-enhancement","tag-diii-domain","tag-glycoprotein-e","tag-monoclonal-antibody","tag-treatment"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Snapshot week 23\/2019 Post-exposure treatment of TBE - TBE Book<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tbenews.com\/tbe\/snapshot-week-23-2019-post-exposure-treatment-of-tbe\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Snapshot week 23\/2019 Post-exposure treatment of TBE - TBE Book\" \/>\n<meta property=\"og:description\" content=\"Matveev et al. Post-exposure administration of chimeric antibody protects mice against European, Siberian, and Far-Eastern subtypes of tick-borne encephalitis virus PLoS ONE 14 (4): e0215075 In most countries, exposure treatment of a TBE infection by immunoglobulin (Ig) preparations is not permitted. The production of Ig preparations has been suspended due to concerns regarding a possible enhancement (antibody dependent enhancement, ADE) of TBE after its administration, e.g. by non-neutralizing TBE antibodies and\/or too low antibody concentrations. However, in Russia the use of TBE Ig preparations is still in use. As an alternative to the use of these preparations for therapeutic treatment, a chimeric monoclonal antibody (chFVN145) which binds to epitopes in the DIII region of glycoprotein E, was been evaluated. Post-exposure treatment of mice with 100 \u03bcg or10 \u03bcg chFVN145 one day after infection with 159 LD50 TBE-Eu virus protected mice in 100% or 50%, respectively. Similar results were obtained using TBE virus subtypes Sib and FE and when treatment was started at day 2 or 3 post infection. Treatment with non-protective doses did not indicate any ADE independent of the subtypes used for infection. These results indicate that chFVN145 would be of value in designing potential anti-TBE preparations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/tbenews.com\/tbe\/snapshot-week-23-2019-post-exposure-treatment-of-tbe\/\" \/>\n<meta property=\"og:site_name\" content=\"TBE Book\" \/>\n<meta property=\"article:published_time\" content=\"2019-06-04T08:48:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-07-08T07:10:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/11\/TBE-Snapshots.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1180\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Michael Br\u00f6ker\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Michael Br\u00f6ker\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-23-2019-post-exposure-treatment-of-tbe\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-23-2019-post-exposure-treatment-of-tbe\\\/\"},\"author\":{\"name\":\"augustine\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#\\\/schema\\\/person\\\/2f903afeb7534df7457d2e3f6d30f64c\"},\"headline\":\"Snapshot week 23\\\/2019 Post-exposure treatment of TBE\",\"datePublished\":\"2019-06-04T08:48:38+00:00\",\"dateModified\":\"2019-07-08T07:10:52+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-23-2019-post-exposure-treatment-of-tbe\\\/\"},\"wordCount\":198,\"publisher\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-23-2019-post-exposure-treatment-of-tbe\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/wp-content\\\/uploads\\\/2017\\\/11\\\/TBE-Snapshots.jpg\",\"keywords\":[\"antibody dependent enhancement\",\"DIII domain\",\"glycoprotein E\",\"monoclonal antibody\",\"treatment\"],\"articleSection\":[\"Snapshot\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-23-2019-post-exposure-treatment-of-tbe\\\/\",\"url\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-23-2019-post-exposure-treatment-of-tbe\\\/\",\"name\":\"Snapshot week 23\\\/2019 Post-exposure treatment of TBE - 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