{"id":14251,"date":"2020-02-17T12:43:11","date_gmt":"2020-02-17T04:43:11","guid":{"rendered":"https:\/\/id-ea.org\/tbe\/?p=14251"},"modified":"2020-02-17T12:44:30","modified_gmt":"2020-02-17T04:44:30","slug":"snapshot-week-8-2020-long-term-antibody-persistence-after-tbe-booster-vaccination-a-modeling-study","status":"publish","type":"post","link":"https:\/\/tbenews.com\/tbe\/snapshot-week-8-2020-long-term-antibody-persistence-after-tbe-booster-vaccination-a-modeling-study\/","title":{"rendered":"Snapshot week 8\/2020 <br> Long-term antibody persistence after TBE booster vaccination: a modeling study"},"content":{"rendered":"<span class=\"cb-itemprop\" itemprop=\"reviewBody\">\n<p class=\"wp-block-paragraph\">Costantini et al.<br>Predicted long-term antibody persistence for a tick-borne encephalitis vaccine: results from a modeling study beyond 10 years after a booster dose following different primary vaccination schedules<br><em>Hum. Vaccin. Immunother<\/em>. 2019, in press, doi.org\/1080\/21645515.2019.1700712<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Regular TBE booster immunizations are recommended for people living in\nor traveling to TBE endemic areas. Long-term clinical studies have shown that\nthe TBE vaccine Encepur (GSK, now Bavarian Nordic) confers neutralizing\nantibodies up to 10 years after the first booster dose in \u226590%\nof vaccinees independent of the vaccination schedule used for primary immunization.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The authors have used several power-law models based on antibody levels\nmeasured in two extension studies in participants followed 5- and 10-years\npost-booster dose to predict the development of antibody levels beyond the time\nperiod covered by clinical trials. Enough protection against TBE is predicted\nfor at least 20 years after booster vaccination with the TBE vaccine, when any\nof the licensed primary three-dose schedules are\ncompleted and a booster dose is administered at 1 or 3 years post-primary\nvaccination (depending on the primary schedule). The model suggests that the\ninterval between booster doses may be increased without compromising the expected\nprotection.<\/p>\n<\/span>","protected":false},"excerpt":{"rendered":"<p>Costantini et al.Predicted long-term antibody persistence for a tick-borne encephalitis vaccine: results from a modeling study beyond 10 years after a booster dose following different primary vaccination schedulesHum. Vaccin. Immunother. 2019, in press, doi.org\/1080\/21645515.2019.1700712 Regular TBE booster immunizations are recommended for people living in or traveling to TBE endemic areas. Long-term clinical studies have shown that the TBE vaccine Encepur (GSK, now Bavarian Nordic) confers neutralizing antibodies up to 10 years after the first booster dose in \u226590% of vaccinees independent of the vaccination schedule used for primary immunization. The authors have used several power-law models based on antibody levels measured in two extension studies in participants followed 5- and 10-years post-booster dose to predict the development of antibody levels beyond the time period covered by clinical trials. Enough protection against TBE is predicted for at least 20 years after booster vaccination with the TBE vaccine, when any of the licensed primary three-dose schedules are completed and a booster dose is administered at 1 or 3 years post-primary vaccination (depending on the primary schedule). The model suggests that the interval between booster doses may be increased without compromising the expected protection.<\/p>\n","protected":false},"author":6,"featured_media":12864,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[18],"tags":[294,295,434,435,316],"coauthors":[81],"class_list":["post-14251","post","type-post","status-publish","format-standard","has-post-thumbnail","category-snapshot","tag-antibody-persistence","tag-booster-vaccination","tag-inceptor","tag-modeling-study","tag-tbe-vaccine"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Snapshot week 8\/2020  Long-term antibody persistence after TBE booster vaccination: a modeling study - TBE Book<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tbenews.com\/tbe\/snapshot-week-8-2020-long-term-antibody-persistence-after-tbe-booster-vaccination-a-modeling-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Snapshot week 8\/2020  Long-term antibody persistence after TBE booster vaccination: a modeling study - TBE Book\" \/>\n<meta property=\"og:description\" content=\"Costantini et al.Predicted long-term antibody persistence for a tick-borne encephalitis vaccine: results from a modeling study beyond 10 years after a booster dose following different primary vaccination schedulesHum. Vaccin. Immunother. 2019, in press, doi.org\/1080\/21645515.2019.1700712 Regular TBE booster immunizations are recommended for people living in or traveling to TBE endemic areas. Long-term clinical studies have shown that the TBE vaccine Encepur (GSK, now Bavarian Nordic) confers neutralizing antibodies up to 10 years after the first booster dose in \u226590% of vaccinees independent of the vaccination schedule used for primary immunization. The authors have used several power-law models based on antibody levels measured in two extension studies in participants followed 5- and 10-years post-booster dose to predict the development of antibody levels beyond the time period covered by clinical trials. Enough protection against TBE is predicted for at least 20 years after booster vaccination with the TBE vaccine, when any of the licensed primary three-dose schedules are completed and a booster dose is administered at 1 or 3 years post-primary vaccination (depending on the primary schedule). The model suggests that the interval between booster doses may be increased without compromising the expected protection.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/tbenews.com\/tbe\/snapshot-week-8-2020-long-term-antibody-persistence-after-tbe-booster-vaccination-a-modeling-study\/\" \/>\n<meta property=\"og:site_name\" content=\"TBE Book\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-17T04:43:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-02-17T04:44:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/11\/TBE-Snapshots.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1180\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Michael Br\u00f6ker\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Michael Br\u00f6ker\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-8-2020-long-term-antibody-persistence-after-tbe-booster-vaccination-a-modeling-study\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-8-2020-long-term-antibody-persistence-after-tbe-booster-vaccination-a-modeling-study\\\/\"},\"author\":{\"name\":\"augustine\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#\\\/schema\\\/person\\\/2f903afeb7534df7457d2e3f6d30f64c\"},\"headline\":\"Snapshot week 8\\\/2020 Long-term antibody persistence after TBE booster vaccination: a modeling study\",\"datePublished\":\"2020-02-17T04:43:11+00:00\",\"dateModified\":\"2020-02-17T04:44:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-8-2020-long-term-antibody-persistence-after-tbe-booster-vaccination-a-modeling-study\\\/\"},\"wordCount\":199,\"publisher\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-8-2020-long-term-antibody-persistence-after-tbe-booster-vaccination-a-modeling-study\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/wp-content\\\/uploads\\\/2017\\\/11\\\/TBE-Snapshots.jpg\",\"keywords\":[\"antibody persistence\",\"booster vaccination\",\"Inceptor\",\"modeling study\",\"TBE vaccine\"],\"articleSection\":[\"Snapshot\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-8-2020-long-term-antibody-persistence-after-tbe-booster-vaccination-a-modeling-study\\\/\",\"url\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-8-2020-long-term-antibody-persistence-after-tbe-booster-vaccination-a-modeling-study\\\/\",\"name\":\"Snapshot week 8\\\/2020 Long-term antibody persistence after TBE booster vaccination: a modeling study - 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