{"id":18479,"date":"2021-09-06T10:40:57","date_gmt":"2021-09-06T02:40:57","guid":{"rendered":"https:\/\/tbenews.com\/tbe\/?p=18479"},"modified":"2021-09-06T10:40:57","modified_gmt":"2021-09-06T02:40:57","slug":"snapshot-week-36-2021are-tbe-vaccine-failures-age-dependent","status":"publish","type":"post","link":"https:\/\/tbenews.com\/tbe\/snapshot-week-36-2021are-tbe-vaccine-failures-age-dependent\/","title":{"rendered":"Snapshot week 36\/2021<br>Are TBE vaccine failures age dependent?"},"content":{"rendered":"<span class=\"cb-itemprop\" itemprop=\"reviewBody\">\n<p class=\"wp-block-paragraph\">Schmitt et al.<br>TBE vaccination breakthrough cases \u2013 Does age matter?<br><em>Vaccines. <\/em>2021; 9(8):932. Doi:10.3390\/vaccines9080932<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">TBE vaccines are highly effective in preventing TBE; however, vaccine failures (breakthrough infections) are sometimes reported.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">An international team has analyzed the age distribution of vaccine failures (VF). In this study, VF was defined as a patient with reported TBE despite having received at least two doses of either FSME Immun or Encepur (both are inactivated whole virus vaccines based on the European subtype) at least two weeks prior to the onset of disease symptoms, and the last dose applied as recommended in the label. A systematic literature review has been carried out, supplemented by data from public health institutes, to identify the relative number of patients in Latvia, Sweden, and southern Germany (Bavaria and Baden-Wuerttemberg) younger or older than 50 years of age.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A total of 173 VF were identified in the three above mentioned countries with a mean age of 62, 55, and 40 years for Sweden, southern Germany, and Latvia, respectively. In Latvia, 65% of the patients were younger than 50 years of age, while in Germany 40% and in Sweden only 19% were younger than 50 years of age. The proportion of TBE cases in individuals younger or older than 50 years were similar in the three countries. However, the proportion of VF was different.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For Sweden \u2013 in contrast to Latvia and Germany \u2013 the proportion was disproportionally higher in the older age group.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The authors discussed various hypotheses for this phenomenon. The higher proportion of VF in older age groups observed in Sweden warrants further investigations.<\/p>\n<\/span>","protected":false},"excerpt":{"rendered":"<p>Schmitt et al.TBE vaccination breakthrough cases \u2013 Does age matter?Vaccines. 2021; 9(8):932. Doi:10.3390\/vaccines9080932 TBE vaccines are highly effective in preventing TBE; however, vaccine failures (breakthrough infections) are sometimes reported. An international team has analyzed the age distribution of vaccine failures (VF). In this study, VF was defined as a patient with reported TBE despite having received at least two doses of either FSME Immun or Encepur (both are inactivated whole virus vaccines based on the European subtype) at least two weeks prior to the onset of disease symptoms, and the last dose applied as recommended in the label. A systematic literature review has been carried out, supplemented by data from public health institutes, to identify the relative number of patients in Latvia, Sweden, and southern Germany (Bavaria and Baden-Wuerttemberg) younger or older than 50 years of age. A total of 173 VF were identified in the three above mentioned countries with a mean age of 62, 55, and 40 years for Sweden, southern Germany, and Latvia, respectively. In Latvia, 65% of the patients were younger than 50 years of age, while in Germany 40% and in Sweden only 19% were younger than 50 years of age. The proportion of TBE cases in individuals younger or older than 50 years were similar in the three countries. However, the proportion of VF was different. For Sweden \u2013 in contrast to Latvia and Germany \u2013 the proportion was disproportionally higher in the older age group. The authors discussed various hypotheses for this phenomenon. The higher proportion of VF in older age groups observed in Sweden warrants further investigations.<\/p>\n","protected":false},"author":1354,"featured_media":12864,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[18],"tags":[204,522,774,213,208],"coauthors":[81],"class_list":["post-18479","post","type-post","status-publish","format-standard","has-post-thumbnail","category-snapshot","tag-germany","tag-latvia","tag-older-adults","tag-sweden","tag-vaccine-failure"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Snapshot week 36\/2021Are TBE vaccine failures age dependent? - TBE Book<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tbenews.com\/tbe\/snapshot-week-36-2021are-tbe-vaccine-failures-age-dependent\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Snapshot week 36\/2021Are TBE vaccine failures age dependent? - TBE Book\" \/>\n<meta property=\"og:description\" content=\"Schmitt et al.TBE vaccination breakthrough cases \u2013 Does age matter?Vaccines. 2021; 9(8):932. Doi:10.3390\/vaccines9080932 TBE vaccines are highly effective in preventing TBE; however, vaccine failures (breakthrough infections) are sometimes reported. An international team has analyzed the age distribution of vaccine failures (VF). In this study, VF was defined as a patient with reported TBE despite having received at least two doses of either FSME Immun or Encepur (both are inactivated whole virus vaccines based on the European subtype) at least two weeks prior to the onset of disease symptoms, and the last dose applied as recommended in the label. A systematic literature review has been carried out, supplemented by data from public health institutes, to identify the relative number of patients in Latvia, Sweden, and southern Germany (Bavaria and Baden-Wuerttemberg) younger or older than 50 years of age. A total of 173 VF were identified in the three above mentioned countries with a mean age of 62, 55, and 40 years for Sweden, southern Germany, and Latvia, respectively. In Latvia, 65% of the patients were younger than 50 years of age, while in Germany 40% and in Sweden only 19% were younger than 50 years of age. The proportion of TBE cases in individuals younger or older than 50 years were similar in the three countries. However, the proportion of VF was different. For Sweden \u2013 in contrast to Latvia and Germany \u2013 the proportion was disproportionally higher in the older age group. The authors discussed various hypotheses for this phenomenon. The higher proportion of VF in older age groups observed in Sweden warrants further investigations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/tbenews.com\/tbe\/snapshot-week-36-2021are-tbe-vaccine-failures-age-dependent\/\" \/>\n<meta property=\"og:site_name\" content=\"TBE Book\" \/>\n<meta property=\"article:published_time\" content=\"2021-09-06T02:40:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/11\/TBE-Snapshots.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1180\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Michael Br\u00f6ker\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Michael Br\u00f6ker\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-36-2021are-tbe-vaccine-failures-age-dependent\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-36-2021are-tbe-vaccine-failures-age-dependent\\\/\"},\"author\":{\"name\":\"Shaqeez\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#\\\/schema\\\/person\\\/2bc2ab1f56f93257537a0ce8de903224\"},\"headline\":\"Snapshot week 36\\\/2021 Are TBE vaccine failures age dependent?\",\"datePublished\":\"2021-09-06T02:40:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-36-2021are-tbe-vaccine-failures-age-dependent\\\/\"},\"wordCount\":260,\"publisher\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-36-2021are-tbe-vaccine-failures-age-dependent\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/wp-content\\\/uploads\\\/2017\\\/11\\\/TBE-Snapshots.jpg\",\"keywords\":[\"Germany\",\"Latvia\",\"older adults\",\"Sweden\",\"vaccine failure\"],\"articleSection\":[\"Snapshot\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-36-2021are-tbe-vaccine-failures-age-dependent\\\/\",\"url\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-36-2021are-tbe-vaccine-failures-age-dependent\\\/\",\"name\":\"Snapshot week 36\\\/2021 Are TBE vaccine failures age dependent? 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Doi:10.3390\/vaccines9080932 TBE vaccines are highly effective in preventing TBE; however, vaccine failures (breakthrough infections) are sometimes reported. An international team has analyzed the age distribution of vaccine failures (VF). In this study, VF was defined as a patient with reported TBE despite having received at least two doses of either FSME Immun or Encepur (both are inactivated whole virus vaccines based on the European subtype) at least two weeks prior to the onset of disease symptoms, and the last dose applied as recommended in the label. A systematic literature review has been carried out, supplemented by data from public health institutes, to identify the relative number of patients in Latvia, Sweden, and southern Germany (Bavaria and Baden-Wuerttemberg) younger or older than 50 years of age. A total of 173 VF were identified in the three above mentioned countries with a mean age of 62, 55, and 40 years for Sweden, southern Germany, and Latvia, respectively. In Latvia, 65% of the patients were younger than 50 years of age, while in Germany 40% and in Sweden only 19% were younger than 50 years of age. The proportion of TBE cases in individuals younger or older than 50 years were similar in the three countries. However, the proportion of VF was different. For Sweden \u2013 in contrast to Latvia and Germany \u2013 the proportion was disproportionally higher in the older age group. The authors discussed various hypotheses for this phenomenon. 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