{"id":21077,"date":"2024-03-25T08:36:00","date_gmt":"2024-03-25T00:36:00","guid":{"rendered":"https:\/\/tbenews.com\/tbe\/?p=21077"},"modified":"2024-03-25T10:34:31","modified_gmt":"2024-03-25T02:34:31","slug":"snapshot-week-13-2024-tbe-vaccination-in-patients-with-rheumatoid-arthritis","status":"publish","type":"post","link":"https:\/\/tbenews.com\/tbe\/snapshot-week-13-2024-tbe-vaccination-in-patients-with-rheumatoid-arthritis\/","title":{"rendered":"Snapshot week 13\/2024
TBE vaccination in patients with rheumatoid arthritis"},"content":{"rendered":"\n

Rack et al.
Immunogenicity of tick-borne-encephalitis-virus-(TBEV)-vaccination and impact of age on humoral and cellular TBEV-specific immune responses in patients with rheumatoid arthritis
Vaccine<\/em>. 2024;42(4):745-752. doi:10.1016\/j.vaccine.2024.01.022<\/p>\n\n\n\n

There are reports indicating that inactivated vaccines like TBE vaccines may induce lower immune responses in immunocompromised individuals.<\/p>\n\n\n\n

A controlled, cross-sectional study has been carried out including 36 patients with rheumatoid arthritis (RA) and 112 age-matched healthy controls (HC), who had received a primary vaccination with TBE vaccine.<\/p>\n\n\n\n

After a booster dose, HC had significantly higher TBE IgG ELISA antibodies (and also higher neutralizing antibodies in a random sample).<\/p>\n\n\n\n

High antibody avidity was less prevalent in RA compared to HC. Higher IgG antibody concentrations were found in RA who had received booster doses compared to those who had not.<\/p>\n\n\n\n

High responders of TBE cellular immune response (IFN\u03b3 ELISpot assay) were more prevalent in HC than in RA. No correlation could be found between TBE humoral and cellular parameters. At the level of T-cell subpopulation, lower effector and memory T-cell responses were present in RA compared to HC, as well as poor natural killer cell reactivity against TBE virus antigens.<\/p>\n\n\n\n

The authors concluded that RA patients showed a negative effect of age on TBE IgG, and immunological benefits of timely booster vaccinations are suggested.<\/p>\n\n\n\n

<\/p>\n<\/span>","protected":false},"excerpt":{"rendered":"

Rack et al.Immunogenicity of tick-borne-encephalitis-virus-(TBEV)-vaccination and impact of age on humoral and cellular TBEV-specific immune responses in patients with rheumatoid arthritisVaccine. 2024;42(4):745-752. doi:10.1016\/j.vaccine.2024.01.022 There are reports indicating that inactivated vaccines like TBE vaccines may induce lower immune responses in immunocompromised individuals. A controlled, cross-sectional study has been carried out including 36 patients with rheumatoid arthritis (RA) and 112 age-matched healthy controls (HC), who had received a primary vaccination with TBE vaccine. After a booster dose, HC had significantly higher TBE IgG ELISA antibodies (and also higher neutralizing antibodies in a random sample). High antibody avidity was less prevalent in RA compared to HC. Higher IgG antibody concentrations were found in RA who had received booster doses compared to those who had not. High responders of TBE cellular immune response (IFN\u03b3 ELISpot assay) were more prevalent in HC than in RA. No correlation could be found between TBE humoral and cellular parameters. At the level of T-cell subpopulation, lower effector and memory T-cell responses were present in RA compared to HC, as well as poor natural killer cell reactivity against TBE virus antigens. The authors concluded that RA patients showed a negative effect of age on TBE IgG, and immunological benefits of timely booster vaccinations are suggested.<\/p>\n","protected":false},"author":1409,"featured_media":20968,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[18],"tags":[295,785,1103,633,1104,1102],"coauthors":[652],"class_list":["post-21077","post","type-post","status-publish","format-standard","has-post-thumbnail","category-snapshot","tag-booster-vaccination","tag-cellular-immune-response","tag-elispot-assay","tag-humoral-immune-response","tag-immunocompromised-patients","tag-rheumatoid-arthritis"],"yoast_head":"\nSnapshot week 13\/2024 TBE vaccination in patients with rheumatoid arthritis - TBE Book<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tbenews.com\/tbe\/snapshot-week-13-2024-tbe-vaccination-in-patients-with-rheumatoid-arthritis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Snapshot week 13\/2024 TBE vaccination in patients with rheumatoid arthritis - TBE Book\" \/>\n<meta property=\"og:description\" content=\"Rack et al.Immunogenicity of tick-borne-encephalitis-virus-(TBEV)-vaccination and impact of age on humoral and cellular TBEV-specific immune responses in patients with rheumatoid arthritisVaccine. 2024;42(4):745-752. doi:10.1016\/j.vaccine.2024.01.022 There are reports indicating that inactivated vaccines like TBE vaccines may induce lower immune responses in immunocompromised individuals. A controlled, cross-sectional study has been carried out including 36 patients with rheumatoid arthritis (RA) and 112 age-matched healthy controls (HC), who had received a primary vaccination with TBE vaccine. After a booster dose, HC had significantly higher TBE IgG ELISA antibodies (and also higher neutralizing antibodies in a random sample). High antibody avidity was less prevalent in RA compared to HC. Higher IgG antibody concentrations were found in RA who had received booster doses compared to those who had not. High responders of TBE cellular immune response (IFN\u03b3 ELISpot assay) were more prevalent in HC than in RA. No correlation could be found between TBE humoral and cellular parameters. At the level of T-cell subpopulation, lower effector and memory T-cell responses were present in RA compared to HC, as well as poor natural killer cell reactivity against TBE virus antigens. 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