{"id":27122,"date":"2025-04-24T09:19:53","date_gmt":"2025-04-24T01:19:53","guid":{"rendered":"https:\/\/tbenews.com\/tbe\/?p=27122"},"modified":"2025-04-24T09:27:50","modified_gmt":"2025-04-24T01:27:50","slug":"snapshot-week-18-2025-single-and-co-administration-of-flavivirus-vaccines","status":"publish","type":"post","link":"https:\/\/tbenews.com\/tbe\/snapshot-week-18-2025-single-and-co-administration-of-flavivirus-vaccines\/","title":{"rendered":"Snapshot week 18\/2025<br>Single and co-administration of flavivirus vaccines"},"content":{"rendered":"<span class=\"cb-itemprop\" itemprop=\"reviewBody\">\n<p class=\"wp-block-paragraph\">Wullimann et al.<br>Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort. <em>PLoS Negl Trop Dis.<\/em> 2025;19:e0012693. doi:10.1371\/journal.pntd.0012693<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">An open-label, non-randomized clinical study was conducted involving 140 healthy participants who received either single or concomitant administration of licensed flavivirus vaccines targeting tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), and yellow fever virus (YFV). The vaccines included an inactivated alum-adjuvanted TBE vaccine, an inactivated alum-adjuvanted JEV vaccine, and a live-attenuated YFV 17D strain vaccine. CD4+ and CD8+ T cell responses were analyzed following vaccination.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">T cell responses were assessed using virus-specific peptides derived from the envelope protein, capsid protein, and non-structural protein 5 of the aforementioned viruses, as well as from Zika virus (ZIKV), to evaluate cross-reactivity and immune activation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The magnitude and specificity of CD4+ and CD8+ T cell responses to the respective viral antigens remained largely unaffected by the concomitant administration of the flavivirus vaccines. Whether administered in the same or in different upper arms, co-delivery had minimal impact on cellular immune responses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The authors concluded that the co-administration of three commonly used, licensed flavivirus vaccines is feasible. It does not increase the risk of adverse events nor significantly compromise the induction of virus-specific neutralizing antibodies (see Snapshot Week 13\/2023) or T cell-mediated immunity.<\/p>\n<\/span>","protected":false},"excerpt":{"rendered":"<p>Wullimann et al.Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort. PLoS Negl Trop Dis. 2025;19:e0012693. doi:10.1371\/journal.pntd.0012693 An open-label, non-randomized clinical study was conducted involving 140 healthy participants who received either single or concomitant administration of licensed flavivirus vaccines targeting tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), and yellow fever virus (YFV). The vaccines included an inactivated alum-adjuvanted TBE vaccine, an inactivated alum-adjuvanted JEV vaccine, and a live-attenuated YFV 17D strain vaccine. CD4+ and CD8+ T cell responses were analyzed following vaccination. T cell responses were assessed using virus-specific peptides derived from the envelope protein, capsid protein, and non-structural protein 5 of the aforementioned viruses, as well as from Zika virus (ZIKV), to evaluate cross-reactivity and immune activation. The magnitude and specificity of CD4+ and CD8+ T cell responses to the respective viral antigens remained largely unaffected by the concomitant administration of the flavivirus vaccines. Whether administered in the same or in different upper arms, co-delivery had minimal impact on cellular immune responses. The authors concluded that the co-administration of three commonly used, licensed flavivirus vaccines is feasible. It does not increase the risk of adverse events nor significantly compromise the induction of virus-specific neutralizing antibodies (see Snapshot Week 13\/2023) or T cell-mediated immunity.<\/p>\n","protected":false},"author":94681,"featured_media":20968,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[18],"tags":[293,1231,987,1232,227],"coauthors":[1108],"class_list":["post-27122","post","type-post","status-publish","format-standard","has-post-thumbnail","category-snapshot","tag-clinical-trial","tag-co-administration","tag-flavivirus-vaccines","tag-t-cell-responses","tag-vaccination"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Snapshot week 18\/2025Single and co-administration of flavivirus vaccines - TBE Book<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tbenews.com\/tbe\/snapshot-week-18-2025-single-and-co-administration-of-flavivirus-vaccines\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Snapshot week 18\/2025Single and co-administration of flavivirus vaccines - TBE Book\" \/>\n<meta property=\"og:description\" content=\"Wullimann et al.Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort. PLoS Negl Trop Dis. 2025;19:e0012693. doi:10.1371\/journal.pntd.0012693 An open-label, non-randomized clinical study was conducted involving 140 healthy participants who received either single or concomitant administration of licensed flavivirus vaccines targeting tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), and yellow fever virus (YFV). The vaccines included an inactivated alum-adjuvanted TBE vaccine, an inactivated alum-adjuvanted JEV vaccine, and a live-attenuated YFV 17D strain vaccine. CD4+ and CD8+ T cell responses were analyzed following vaccination. T cell responses were assessed using virus-specific peptides derived from the envelope protein, capsid protein, and non-structural protein 5 of the aforementioned viruses, as well as from Zika virus (ZIKV), to evaluate cross-reactivity and immune activation. The magnitude and specificity of CD4+ and CD8+ T cell responses to the respective viral antigens remained largely unaffected by the concomitant administration of the flavivirus vaccines. Whether administered in the same or in different upper arms, co-delivery had minimal impact on cellular immune responses. The authors concluded that the co-administration of three commonly used, licensed flavivirus vaccines is feasible. It does not increase the risk of adverse events nor significantly compromise the induction of virus-specific neutralizing antibodies (see Snapshot Week 13\/2023) or T cell-mediated immunity.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/tbenews.com\/tbe\/snapshot-week-18-2025-single-and-co-administration-of-flavivirus-vaccines\/\" \/>\n<meta property=\"og:site_name\" content=\"TBE Book\" \/>\n<meta property=\"article:published_time\" content=\"2025-04-24T01:19:53+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-24T01:27:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2023\/12\/TBE-Snapshots.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1180\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"logesan\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"logesan\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-18-2025-single-and-co-administration-of-flavivirus-vaccines\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-18-2025-single-and-co-administration-of-flavivirus-vaccines\\\/\"},\"author\":{\"name\":\"logesan\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#\\\/schema\\\/person\\\/eea00490409f8d848a28485d0f68fac3\"},\"headline\":\"Snapshot week 18\\\/2025 Single and co-administration of flavivirus vaccines\",\"datePublished\":\"2025-04-24T01:19:53+00:00\",\"dateModified\":\"2025-04-24T01:27:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-18-2025-single-and-co-administration-of-flavivirus-vaccines\\\/\"},\"wordCount\":229,\"publisher\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-18-2025-single-and-co-administration-of-flavivirus-vaccines\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/wp-content\\\/uploads\\\/2023\\\/12\\\/TBE-Snapshots.jpg\",\"keywords\":[\"clinical trial\",\"co-administration\",\"flavivirus vaccines\",\"T cell responses\",\"vaccination\"],\"articleSection\":[\"Snapshot\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-18-2025-single-and-co-administration-of-flavivirus-vaccines\\\/\",\"url\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/snapshot-week-18-2025-single-and-co-administration-of-flavivirus-vaccines\\\/\",\"name\":\"Snapshot week 18\\\/2025 Single and co-administration of flavivirus vaccines - 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PLoS Negl Trop Dis. 2025;19:e0012693. doi:10.1371\/journal.pntd.0012693 An open-label, non-randomized clinical study was conducted involving 140 healthy participants who received either single or concomitant administration of licensed flavivirus vaccines targeting tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), and yellow fever virus (YFV). The vaccines included an inactivated alum-adjuvanted TBE vaccine, an inactivated alum-adjuvanted JEV vaccine, and a live-attenuated YFV 17D strain vaccine. CD4+ and CD8+ T cell responses were analyzed following vaccination. T cell responses were assessed using virus-specific peptides derived from the envelope protein, capsid protein, and non-structural protein 5 of the aforementioned viruses, as well as from Zika virus (ZIKV), to evaluate cross-reactivity and immune activation. 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