{"id":4237,"date":"2017-07-24T15:44:41","date_gmt":"2017-07-24T07:44:41","guid":{"rendered":"http:\/\/www.id-ea.info\/?p=4237"},"modified":"2023-05-12T17:03:08","modified_gmt":"2023-05-12T09:03:08","slug":"tbe12b30","status":"publish","type":"post","link":"https:\/\/tbenews.com\/tbe\/tbe12b30\/","title":{"rendered":"Slovenia"},"content":{"rendered":"\n
<\/a><\/span>
\n

TBE in Slovenia<\/strong><\/h1>\n<\/div>\n\n\n\n

Zoran Simonovi\u0107 and Tamara Vukovi\u0107 Jankovi\u0107<\/strong><\/p>\n\n\n\n

ECDC risk status: endemic<\/strong><\/h3>\n\n\n\n

(data as of end 2022)<\/em><\/p>\n\n\n\n

History and current situation<\/strong><\/h3>\n\n\n\n

TBE is endemic in Slovenia, and the incidence rate is one of the highest in the EU. In Slovenia, TBE virus was confirmed for the first time in 1953 with isolation of the virus from a patient\u2019s blood.1<\/sup><\/a> In 1955, the virus was isolated from a tick Ixodes ricinus.<\/em>2<\/sup><\/a><\/p>\n\n\n\n

Notification of TBE cases as well as deaths due to TBE has been mandatory in Slovenia since 1977. Only cases with central nervous system involvement and laboratory confirmation are notified. Surveillance data has been collected within the communicable diseases surveillance system by the National Institute of Public Health of Slovenia (NIPH).<\/p>\n\n\n\n

The number of TBE reported cases in Slovenia varies every year. In the period from 1983 to 2016, the number of annually reported TBE cases was between 62 and 531 (incidence rates between 3.0 and 26.6\/100,000), which amounts to a mean of 206 cases\/year, and a mean annual incidence rate of 10.3\/100.000. In contrast to reports on increasingly higher incidence rates of TBE during the last two decades from many endemic countries, in Slovenia the reported incidence rates during the last 35 years have shown no apparent increasing or decreasing trend. Occurrence of the disease presumably fluctuates due to climatic factors influencing tick activity and population number of small forest mammals, different weather conditions during summer months in different years and other possible factors (e.g., changes in leisure activities) that have not been investigated yet.<\/p>\n\n\n\n

TBE virus is present in all Slovenian regions. Although some regions in Slovenia have higher incidence of TBE than others, TBE occurs throughout the country, with the most affected areas in the north and central regions (Figure 1). In some administrative units average annual TBE incidence rates exceed 45\/100,000 (Figure 2).<\/p>\n\n\n\n

TBE infections occur seasonally, in Slovenia mostly between April and November, with a peak in June and July.5<\/sup><\/a> In the recent years an increase of the cases in the elderly has been observed. Since 1994, TBE incidence rates have been the highest in the 55\u201364 age group in most years, with males being more frequently affected than females.6<\/sup><\/a> In men, the 65\u201374 age group and in women the 45\u201354 age group followed, with the second highest rates in most years. In contrast to the TBE incidence, the disease burden expressed in DALYs was higher in children aged 5\u201314 years than in adults aged 50\u201374 years.7<\/sup><\/a><\/p>\n\n\n\n

People who are staying in the endemic areas (temporarily or permanently) have a higher risk for TBE infection. These are mainly people working in forestry, wood and wood-processing industries and construction. The risk is also higher among farmers, if their farmlands are located near forested areas, which present a natural habitat for ticks. There have also been observations of increased TBE incidence among people who visit forests for recreational purpose or forest fruit-picking. An epidemiological study that included 1,564 cases of TBE in Slovenia showed that 82.3% of cases had a tick bite on one or multiple sites on the body. The estimated duration of tick attachment was less than 6 h in 23.5% of TBE cases. Long attachments (more than 24 h) were reported by 10% of the patients. The tick bite occurred while the TBE patients were engaged in leisure time activities (sports or camping, 32.8%), mushroom or berry picking (30.2%), or farming (23.3%). Almost two-thirds of TBE patients reported that they had practiced at least one of the recommended preventive measures, most frequently self-inspection, and least often repellent use.8<\/sup><\/a><\/p>\n\n\n\n

Overview of TBE in Slovenia<\/strong><\/h3>\n\n\n\n
\n\n\n\n\n\n\n\n
Table 1: Virus, vector, transmission of TBE in Slovenia<\/th>\n<\/tr>\n
Viral subtypes, distribution<\/td>\nEuropean subtype; great heterogeneity of the viruses with geographical clustering of viruses with the same genetic characteristics.9<\/sup><\/a><\/td>\n<\/tr>\n
Reservoir animals<\/td>\nRodents; TBE virus antibodies were detected in 5.9% of rodent sera. Bank voles had higher rate of infection than mice.10<\/sup><\/a><\/td>\n<\/tr>\n
Infected tick species (%)<\/td>\nIn Slovenia the main vector is Ixodes ricinus<\/em> and the prevalence of TBE ticks infection is 0.47%.11<\/sup><\/a><\/td>\n<\/tr>\n
Dairy product transmission<\/td>\nCases of alimentary TBE 2012\u20132014: 6 (4 in small outbreak in 2012).12<\/sup><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>
\n\n\n\n
\n\n\n\n\n\n\n\n\n\n\n
Table 2: TBE reporting and vaccine prevention in Slovenia<\/th>\n<\/tr>\n
Mandatory TBE reporting13,14<\/sup><\/a><\/td>\nReporting is mandatory. Only confirmed cases are reported formally to clinicians.Clinically diagnosed CNS infection of TBE must be confirmed by at least one of the following:\n
    \n
  • the presence of specific serum IgM and IgG antibodies<\/li>\n
  • the presence of specific IgM antibodies in CSF<\/li>\n
  • IgG seroconversion to TBE virus<\/li>\n
  • the presence of TBE virus genome in clinical specimen<\/li>\n
  • isolation of TBE virus from clinical specimen.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Other TBE-surveillance<\/td>\n–<\/td>\n<\/tr>\n
Special clinical features<\/td>\n–<\/td>\n<\/tr>\n
Available vaccines<\/td>\nFSME-Immun and Encepur.15<\/sup><\/a><\/td>\n<\/tr>\n
Vaccination recommendations and reimbursement16,17,18,19,20<\/sup><\/a><\/td>\nTBE vaccination was introduced in 1986. National TBE vaccination policy and recommendation implemented only for high-risk groups:\n
    \n
  • since 1986, mandatory for high-risk workers (eg. foresters, hunters, farmers, gardeners, soldiers, laboratory workers) – reimbursed by employers<\/li>\n
  • since 1990, mandatory for students at high risk (eg. forestry, wood processing ) – reimbursed within compulsory national health insurance<\/li>\n
  • since 1991, recommended for all individuals living in or travelling to endemic areas including children from one year of age – paid by vaccinated individuals themselves.<\/li>\n<\/ul>\n

    In 2019, the vaccination against TBE, funded by the Health Insurance Institute of Slovenia, is available to children born in 2016 and adults born in 1970. Vaccination is performed by selected personal physicians or paediatricians.
    Persons from these age groups who have already been vaccinated against tick-borne meningoencephalitis are eligible for the next three doses of the TBE vaccine (primary vaccination or booster).
    Previously unvaccinated adults 49 years old and children 3 years old, will be included in the vaccination program every year, thus gradually increasing the protection of the Slovenian population against TBE.<\/p>\n<\/td>\n<\/tr>\n

Vaccine uptake by age group\/ risk group\/ general population<\/td>\nIn 2007, general population aged 15 years and more who reported ever to have been vaccinated against TBE was 12.4 %. No further estimations of vaccine coverage have been performed. In 2014, according to official data from National Institute of Public Health of Slovenia, the number increased to 16%. No further estimates of vaccine coverage have been performed.18<\/sup><\/a><\/td>\n<\/tr>\n
Name, address\/website of TBE National Reference Center<\/td>\nNational Institute of Public Health of Sloveniahttp:\/\/www.nijz.si\/en<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>
\n\n\n\n
\n
\n

Figure 1:<\/span> Reported TBE cases in Slovenia between 2008 and 2014 by region3<\/sup><\/h3>\n<\/div>\n
\"\"<\/a><\/figure>
<\/div>\n<\/div>
\n\n\n\n
\n
\n

Figure 2:<\/span> Average annual TBE incidence rates by administrative unit (2003\u20132012)4<\/sup><\/h3>\n<\/div>\n
\"\"<\/a><\/figure>
<\/div>\n<\/div>
\n\n\n\n
\n
\n

Figure 3:<\/span> Burden of TBE in Slovenia over time3,4<\/sup><\/a><\/h3>\n<\/div>\n
\"\"<\/a><\/figure>
<\/div>\n
Source data \n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
Year<\/th>Number of Cases<\/th>Incidence \/ 105<\/sup><\/th>\n<\/tr>\n<\/thead>\n
1983<\/td>111<\/td>5.56<\/td>\n<\/tr>\n
1984<\/td>209<\/td>10.47<\/td>\n<\/tr>\n
1985<\/td>274<\/td>13.72<\/td>\n<\/tr>\n
1986<\/td>226<\/td>11.32<\/td>\n<\/tr>\n
1987<\/td>107<\/td>5.36<\/td>\n<\/tr>\n
1988<\/td>114<\/td>5.71<\/td>\n<\/tr>\n
1989<\/td>65<\/td>3.26<\/td>\n<\/tr>\n
1990<\/td>104<\/td>5.21<\/td>\n<\/tr>\n
1991<\/td>118<\/td>5.91<\/td>\n<\/tr>\n
1992<\/td>80<\/td>4.01<\/td>\n<\/tr>\n
1993<\/td>197<\/td>9.87<\/td>\n<\/tr>\n
1994<\/td>531<\/td>26.59<\/td>\n<\/tr>\n
1995<\/td>157<\/td>7.86<\/td>\n<\/tr>\n
1996<\/td>406<\/td>20.33<\/td>\n<\/tr>\n
1997<\/td>274<\/td>13.72<\/td>\n<\/tr>\n
1998<\/td>137<\/td>6.86<\/td>\n<\/tr>\n
1999<\/td>150<\/td>7.51<\/td>\n<\/tr>\n
2000<\/td>196<\/td>9.82<\/td>\n<\/tr>\n
2001<\/td>260<\/td>13.02<\/td>\n<\/tr>\n
2002<\/td>262<\/td>13.12<\/td>\n<\/tr>\n
2003<\/td>282<\/td>14.12<\/td>\n<\/tr>\n
2004<\/td>199<\/td>9.97<\/td>\n<\/tr>\n
2005<\/td>297<\/td>14.90<\/td>\n<\/tr>\n
2006<\/td>372<\/td>18.63<\/td>\n<\/tr>\n
2007<\/td>199<\/td>9.90<\/td>\n<\/tr>\n
2008<\/td>251<\/td>12.40<\/td>\n<\/tr>\n
2009<\/td>304<\/td>14.90<\/td>\n<\/tr>\n
2010<\/td>166<\/td>8.10<\/td>\n<\/tr>\n
2011<\/td>247<\/td>12.00<\/td>\n<\/tr>\n
2012<\/td>164<\/td>8.00<\/td>\n<\/tr>\n
2013<\/td>309<\/td>15.00<\/td>\n<\/tr>\n
2014<\/td>100<\/td>4.90<\/td>\n<\/tr>\n
2015<\/td>62<\/td>3.00<\/td>\n<\/tr>\n
2016<\/td>83<\/td>4.00<\/td>\n<\/tr>\n
2017<\/td>102<\/td>4.90<\/td>\n<\/tr>\n
2018<\/td>153<\/td>7.60<\/td>\n<\/tr>\n
2019<\/td>111<\/td>4.21<\/td>\n<\/tr>\n
2020<\/td>187<\/td>9.35<\/td>\n<\/tr>\n
2021<\/td>62<\/td>2.94<\/td>\n<\/tr>\n
2022<\/td>126<\/td>5.97<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/a><\/div>\n<\/div>
\n\n\n\n
\n
\n

Figure 4:<\/span> Age and gender specific incidence rates of TBE in Slovenia in year 20183<\/sup><\/a><\/h3>\n<\/div>\n
\"\"<\/a><\/figure>
<\/div>\n<\/div>
\n\n\n\n
\n
\n

Figure 5:<\/span> Mean annual incidence per 100,000 of tick-borne encephalitis, by age and gender, Slovenia, 2009\u201320138<\/sup><\/a><\/h3>\n<\/div>\n
\"\"<\/a><\/figure>
<\/div>\n<\/div>
\n\n\n\n
\n
\n

Figure 6:<\/span> Geographical distribution of TBE virus isolation from rodents only, 2005\u20132008. TBEV-isolation in Slovenia10<\/sup><\/a><\/h3>\n<\/div>\n
\"\"<\/a><\/figure>
<\/div>\n<\/div>
\n\n\n\n
\n
\n

Figure 7:<\/span> Map of municipalities in Slovenia, showing sites where tick-borne encephalitis virus (TBEV) was detected in rodents (represented in dots) and municipalities (gray coloured) where rodents were captured (2000\u20132008).<\/h3>\n<\/div>\n
\"\"<\/a><\/figure>
<\/div>\n<\/div>\n\n\n\n

Contact:<\/h3>\n\n\n\n

Zoran.simonovic@nijz.si<\/p>\n\n\n\n

Citation:<\/h3>\n\n\n\n

Simonovi\u0107 Z, Vukovi\u0107-Jankovi\u0107 T. TBE in Slovenia. Chapter 12b. In: Dobler G, Erber W, Br\u00f6ker M, Schmitt HJ, eds. The TBE Book<\/em>. 6th ed. Singapore: Global Health Press;2023. doi:10.33442\/26613980_12b30-6<\/p>\n\n\n\n

References<\/h3>\n\n\n\n
    \n
  1. <\/a>Vesenjak-Zmijanac J, Bedjani\u010d M, Rus S, Kmet J. Virus meningoencephalitis in Slovenia: isolation of the causative agent. Bull WHO<\/em>. 1955;12:513-20.<\/li>\n\n\n\n
  2. <\/a>Likar M, Kmet J. Virus meningo-encephalitis in Slovenia: isolation of the virus from the ticks I. ricinus. Bull WHO<\/em>. 1956;15(1-2):275-9.<\/li>\n\n\n\n
  3. <\/a>NIJZ podatkovni portal, Available at: http:\/\/www.nijz.si\/sl\/klopni-meningoencefalitis-razsirjenost-in-zascita [Accessed April 2017]<\/li>\n\n\n\n
  4. <\/a>Vitek-Grgi\u010d M. Epidemiologija klopnega meningoencefalitisa in humane granulocitne anaplazmoze v Sloveniji. Klinika za infekcijske bolezni in vro\u010dinska stanja, UKC Ljubljana. Klopni meningoencefalitis in humana granulocitna anaplazmoza<\/em>. 2014;1:17-24.<\/li>\n\n\n\n
  5. <\/a>Kraigher A, Matja\u0161i\u010d M, Ho\u010devar-Grom A, Turk K. TBE surveillance in Slovenia. Antibiotica Monitor<\/em>. 1996;12:121-3.<\/li>\n\n\n\n
  6. <\/a>Grgi\u010d-Vitek M, Klavs I. High burden of tick-borne encephalitis in Slovenia \u2013 challenge for vaccination policy. Vaccine<\/em>. 2011;29:5178-83.<\/li>\n\n\n\n
  7. <\/a>Fafangel M, Cassini A, Colzani E, Klavs I, Grgi\u010d Vitek M, U\u010dakar V, et al. Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013. Euro Surveill<\/em>. 2017;22:30509.<\/li>\n\n\n\n
  8. <\/a>Blasko-Markic M, Socan M. Tick-borne encephalitis in Slovenia: data from a questionnaire survey. Vector Borne Zoonotic Dis<\/em>. 2012;12:496-502.<\/li>\n\n\n\n
  9. <\/a>Fajs L, Durmi\u0161i E, Knap N, Strle F, Av\u0161i\u010d-\u017dupanc T. Phylogeographic characterization of tick-borne encephalitis virus from patients, rodents and ticks in Slovenia. PloS One<\/em>. 2012;7:1-8<\/li>\n\n\n\n
  10. <\/a>Knap N, Korva M, Dolin\u0161ek V, Sekirnik M, Trilar T, Av\u0161i\u010d-\u017dupanc T. Patterns of Tick-Borne Encephalitis Virus Infection in Rodents in Slovenia. Vector Borne Zoonotic Dis. <\/em>2012;12:236-42.<\/li>\n\n\n\n
  11. <\/a>Durmi\u0161i E, Knap N, Saksida A, Trilar T, Duh D, Av\u0161i\u010d-\u017dupanc T. Prevalence and molecular characterization of tick-borne encephalitis virus in i. ricinus ticks collected in Slovenia. Vector Borne Zoonotic Dis<\/em>. 2011;11:659-64.<\/li>\n\n\n\n
  12. <\/a>Hudopisk N, Korva M, Janet E, Simetinger M, Grgi\u010d-Vitek M, Guben\u0161ek J, et al. Tick-borne encephalitis associated with consumption of raw goat milk, Slovenia, 2012. Emerg Infect Dis<\/em>. 2013;19:806-8.<\/li>\n\n\n\n
  13. <\/a>So\u010dan M, \u0160ubelj M. Definicije prijavljenih nalezljivih bolezni za namene epidemiolo\u0161kega spremljanja. Ljubljana : In\u0161titut za varovanje zdravja Republike Slovenije, 2012.<\/li>\n\n\n\n
  14. <\/a>Simonovi\u0107 Z. TBE epidemiology in Slovenia, Poster 17th ISW TBE Meeting, 29 – 30 January 2015, Vienna.<\/li>\n\n\n\n
  15. <\/a>Database of medicines in Slovenia. Available at: http:\/\/www.cbz.si\/cbz\/bazazdr2.nsf\/Search?SearchView&Query=(%5BSIATCKLA%5D=J07BA01*)&SearchOrder=4&SearchMax=301 [Accessed July 2017]<\/li>\n\n\n\n
  16. <\/a>Zavadska D, Anca I, Andr\u00e9 F et al. Recommendations for tick-borne encephalitis vaccination from the Central European Vaccination Awareness Group (CEVAG). Hum Vaccin Immunother<\/em>. 2013;9:362\u201374.<\/li>\n\n\n\n
  17. <\/a>NIPH. Program cepljenja in za\u0161\u010dite z zdravili za leto 2016. Ljubljana : Nacionalni in\u0161titut za javno zdravje, 2016. Available at: : http:\/\/www.nijz.si\/sl\/program-cepljenja-inzascite-z-zdravili-za-leto-2016 [Accessed June 2017]<\/li>\n\n\n\n
  18. <\/a>Grgi\u010d-Vitek M, Klavs I. Low coverage and predictors of vaccination uptake against tick-borne encephalitis in Slovenia. Eur J Public Health.<\/em> 2012;22:182-6.<\/li>\n\n\n\n
  19. <\/a>NIPH. Recommendations for vaccination against tick-borne meningoencephalitis, May 30th, 2019. Available at: https:\/\/www.nijz.si\/sites\/www.nijz.si\/files\/uploaded\/kme-priporocila_za_cepljenje_proti_kme_2019_maj.pdf [Accessed March 2020]<\/li>\n\n\n\n
  20. <\/a>NIPH. Frequently Asked Questions and Answers on Introducing TBE Vaccination into the Vaccination Program. Available at: https:\/\/www.nijz.si\/sl\/najpogostejsa-vprasanja-in-odgovori-o-uvedbi-cepljenja-proti-kme-v-program-cepljenja [Accessed March 2020]<\/li>\n<\/ol>\n<\/span>","protected":false},"excerpt":{"rendered":"

    TBE in Slovenia Zoran Simonovi\u0107 and Tamara Vukovi\u0107 Jankovi\u0107 ECDC risk status: endemic (data as of end 2022) History and current situation TBE is endemic in Slovenia, and the incidence rate is one of the highest in the EU. In Slovenia, TBE virus was confirmed for the first time in 1953 with isolation of the virus from a patient\u2019s blood.1 In 1955, the virus was isolated from a tick Ixodes ricinus.2 Notification of TBE cases as well as deaths due to TBE has been mandatory in Slovenia since 1977. Only cases with central nervous system involvement and laboratory confirmation are notified. Surveillance data has been collected within the communicable diseases surveillance system by the National Institute of Public Health of Slovenia (NIPH). The number of TBE reported cases in Slovenia varies every year. In the period from 1983 to 2016, the number of annually reported TBE cases was between 62 and 531 (incidence rates between 3.0 and 26.6\/100,000), which amounts to a mean of 206 cases\/year, and a mean annual incidence rate of 10.3\/100.000. In contrast to reports on increasingly higher incidence rates of TBE during the last two decades from many endemic countries, in Slovenia the reported incidence rates during the last 35 years have shown no apparent increasing or decreasing trend. Occurrence of the disease presumably fluctuates due to climatic factors influencing tick activity and population number of small forest mammals, different weather conditions during summer months in different years and other possible factors (e.g., changes in leisure activities) that have not been investigated yet. TBE virus is present in all Slovenian regions. Although some regions in Slovenia have higher incidence of TBE than others, TBE occurs throughout the country, with the most affected areas in the north and central regions (Figure 1). In some administrative units average annual TBE incidence rates exceed 45\/100,000 (Figure 2). TBE infections occur seasonally, in Slovenia mostly between April and November, with a peak in June and July.5 In the recent years an increase of the cases in the elderly has been observed. Since 1994, TBE incidence rates have been the highest in the 55\u201364 age group in most years, with males being more frequently affected than females.6 In men, the 65\u201374 age group and in women the 45\u201354 age group followed, with the second highest rates in most years. In contrast to the TBE incidence, the disease burden expressed in DALYs was higher in children aged 5\u201314 years than in adults aged 50\u201374 years.7 People who are staying in the endemic areas (temporarily or permanently) have a higher risk for TBE infection. These are mainly people working in forestry, wood and wood-processing industries and construction. The risk is also higher among farmers, if their farmlands are located near forested areas, which present a natural habitat for ticks. There have also been observations of increased TBE incidence among people who visit forests for recreational purpose or forest fruit-picking. An epidemiological study that included 1,564 cases of TBE in Slovenia showed that 82.3% of cases had a tick bite on one or multiple sites on the body. The estimated duration of tick attachment was less than 6 h in 23.5% of TBE cases. Long attachments (more than 24 h) were reported by 10% of the patients. The tick bite occurred while the TBE patients were engaged in leisure time activities (sports or camping, 32.8%), mushroom or berry picking (30.2%), or farming (23.3%). Almost two-thirds of TBE patients reported that they had practiced at least one of the recommended preventive measures, most frequently self-inspection, and least often repellent use.8 Overview of TBE in Slovenia Table 1: Virus, vector, transmission of TBE in Slovenia Viral subtypes, distribution European subtype; great heterogeneity of the viruses with geographical clustering of viruses with the same genetic characteristics.9 Reservoir animals Rodents; TBE virus antibodies were detected in 5.9% of rodent sera. Bank voles had higher rate of infection than mice.10 Infected tick species (%) In Slovenia the main vector is Ixodes ricinus and the prevalence of TBE ticks infection is 0.47%.11 Dairy product transmission Cases of alimentary TBE 2012\u20132014: 6 (4 in small outbreak in 2012).12 Table 2: TBE reporting and vaccine prevention in Slovenia Mandatory TBE reporting13,14 Reporting is mandatory. Only confirmed cases are reported formally to clinicians.Clinically diagnosed CNS infection of TBE must be confirmed by at least one of the following: the presence of specific serum IgM and IgG antibodies the presence of specific IgM antibodies in CSF IgG seroconversion to TBE virus the presence of TBE virus genome in clinical specimen isolation of TBE virus from clinical specimen. Other TBE-surveillance – Special clinical features – Available vaccines FSME-Immun and Encepur.15 Vaccination recommendations and reimbursement16,17,18,19,20 TBE vaccination was introduced in 1986. National TBE vaccination policy and recommendation implemented only for high-risk groups: since 1986, mandatory for high-risk workers (eg. foresters, hunters, farmers, gardeners, soldiers, laboratory workers) – reimbursed by employers since 1990, mandatory for students at high risk (eg. forestry, wood processing ) – reimbursed within compulsory national health insurance since 1991, recommended for all individuals living in or travelling to endemic areas including children from one year of age – paid by vaccinated individuals themselves. In 2019, the vaccination against TBE, funded by the Health Insurance Institute of Slovenia, is available to children born in 2016 and adults born in 1970. Vaccination is performed by selected personal physicians or paediatricians.Persons from these age groups who have already been vaccinated against tick-borne meningoencephalitis are eligible for the next three doses of the TBE vaccine (primary vaccination or booster).Previously unvaccinated adults 49 years old and children 3 years old, will be included in the vaccination program every year, thus gradually increasing the protection of the Slovenian population against TBE. Vaccine uptake by age group\/ risk group\/ general population In 2007, general population aged 15 years and more who reported ever to have been vaccinated against TBE was 12.4 %. No further estimations of vaccine coverage have been performed. In 2014, according to official data from National<\/p>\n","protected":false},"author":3,"featured_media":12836,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"categories":[38],"tags":[],"coauthors":[65],"class_list":["post-4237","post","type-post","status-publish","format-standard","has-post-thumbnail","category-tbe-countries-slovenia"],"yoast_head":"\nSlovenia - TBE Book<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tbenews.com\/tbe\/tbe12b30\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Slovenia - TBE Book\" \/>\n<meta property=\"og:description\" content=\"TBE in Slovenia Zoran Simonovi\u0107 and Tamara Vukovi\u0107 Jankovi\u0107 ECDC risk status: endemic (data as of end 2022) History and current situation TBE is endemic in Slovenia, and the incidence rate is one of the highest in the EU. In Slovenia, TBE virus was confirmed for the first time in 1953 with isolation of the virus from a patient\u2019s blood.1 In 1955, the virus was isolated from a tick Ixodes ricinus.2 Notification of TBE cases as well as deaths due to TBE has been mandatory in Slovenia since 1977. Only cases with central nervous system involvement and laboratory confirmation are notified. Surveillance data has been collected within the communicable diseases surveillance system by the National Institute of Public Health of Slovenia (NIPH). The number of TBE reported cases in Slovenia varies every year. In the period from 1983 to 2016, the number of annually reported TBE cases was between 62 and 531 (incidence rates between 3.0 and 26.6\/100,000), which amounts to a mean of 206 cases\/year, and a mean annual incidence rate of 10.3\/100.000. In contrast to reports on increasingly higher incidence rates of TBE during the last two decades from many endemic countries, in Slovenia the reported incidence rates during the last 35 years have shown no apparent increasing or decreasing trend. Occurrence of the disease presumably fluctuates due to climatic factors influencing tick activity and population number of small forest mammals, different weather conditions during summer months in different years and other possible factors (e.g., changes in leisure activities) that have not been investigated yet. TBE virus is present in all Slovenian regions. Although some regions in Slovenia have higher incidence of TBE than others, TBE occurs throughout the country, with the most affected areas in the north and central regions (Figure 1). In some administrative units average annual TBE incidence rates exceed 45\/100,000 (Figure 2). TBE infections occur seasonally, in Slovenia mostly between April and November, with a peak in June and July.5 In the recent years an increase of the cases in the elderly has been observed. Since 1994, TBE incidence rates have been the highest in the 55\u201364 age group in most years, with males being more frequently affected than females.6 In men, the 65\u201374 age group and in women the 45\u201354 age group followed, with the second highest rates in most years. In contrast to the TBE incidence, the disease burden expressed in DALYs was higher in children aged 5\u201314 years than in adults aged 50\u201374 years.7 People who are staying in the endemic areas (temporarily or permanently) have a higher risk for TBE infection. These are mainly people working in forestry, wood and wood-processing industries and construction. The risk is also higher among farmers, if their farmlands are located near forested areas, which present a natural habitat for ticks. There have also been observations of increased TBE incidence among people who visit forests for recreational purpose or forest fruit-picking. An epidemiological study that included 1,564 cases of TBE in Slovenia showed that 82.3% of cases had a tick bite on one or multiple sites on the body. The estimated duration of tick attachment was less than 6 h in 23.5% of TBE cases. Long attachments (more than 24 h) were reported by 10% of the patients. The tick bite occurred while the TBE patients were engaged in leisure time activities (sports or camping, 32.8%), mushroom or berry picking (30.2%), or farming (23.3%). Almost two-thirds of TBE patients reported that they had practiced at least one of the recommended preventive measures, most frequently self-inspection, and least often repellent use.8 Overview of TBE in Slovenia Table 1: Virus, vector, transmission of TBE in Slovenia Viral subtypes, distribution European subtype; great heterogeneity of the viruses with geographical clustering of viruses with the same genetic characteristics.9 Reservoir animals Rodents; TBE virus antibodies were detected in 5.9% of rodent sera. Bank voles had higher rate of infection than mice.10 Infected tick species (%) In Slovenia the main vector is Ixodes ricinus and the prevalence of TBE ticks infection is 0.47%.11 Dairy product transmission Cases of alimentary TBE 2012\u20132014: 6 (4 in small outbreak in 2012).12 Table 2: TBE reporting and vaccine prevention in Slovenia Mandatory TBE reporting13,14 Reporting is mandatory. Only confirmed cases are reported formally to clinicians.Clinically diagnosed CNS infection of TBE must be confirmed by at least one of the following: the presence of specific serum IgM and IgG antibodies the presence of specific IgM antibodies in CSF IgG seroconversion to TBE virus the presence of TBE virus genome in clinical specimen isolation of TBE virus from clinical specimen. Other TBE-surveillance – Special clinical features – Available vaccines FSME-Immun and Encepur.15 Vaccination recommendations and reimbursement16,17,18,19,20 TBE vaccination was introduced in 1986. National TBE vaccination policy and recommendation implemented only for high-risk groups: since 1986, mandatory for high-risk workers (eg. foresters, hunters, farmers, gardeners, soldiers, laboratory workers) – reimbursed by employers since 1990, mandatory for students at high risk (eg. forestry, wood processing ) – reimbursed within compulsory national health insurance since 1991, recommended for all individuals living in or travelling to endemic areas including children from one year of age – paid by vaccinated individuals themselves. In 2019, the vaccination against TBE, funded by the Health Insurance Institute of Slovenia, is available to children born in 2016 and adults born in 1970. Vaccination is performed by selected personal physicians or paediatricians.Persons from these age groups who have already been vaccinated against tick-borne meningoencephalitis are eligible for the next three doses of the TBE vaccine (primary vaccination or booster).Previously unvaccinated adults 49 years old and children 3 years old, will be included in the vaccination program every year, thus gradually increasing the protection of the Slovenian population against TBE. Vaccine uptake by age group\/ risk group\/ general population In 2007, general population aged 15 years and more who reported ever to have been vaccinated against TBE was 12.4 %. No further estimations of vaccine coverage have been performed. In 2014, according to official data from National\" \/>\n<meta property=\"og:url\" content=\"https:\/\/tbenews.com\/tbe\/tbe12b30\/\" \/>\n<meta property=\"og:site_name\" content=\"TBE Book\" \/>\n<meta property=\"article:published_time\" content=\"2017-07-24T07:44:41+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-12T09:03:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/07\/Slovenia.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1180\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Administrator admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Administrator admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/tbe12b30\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/tbe12b30\\\/\"},\"author\":{\"name\":\"Administrator admin\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#\\\/schema\\\/person\\\/dd436937ad52c89f92315a6488c1d2c7\"},\"headline\":\"Slovenia\",\"datePublished\":\"2017-07-24T07:44:41+00:00\",\"dateModified\":\"2023-05-12T09:03:08+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/tbe12b30\\\/\"},\"wordCount\":1612,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/tbe12b30\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/wp-content\\\/uploads\\\/2017\\\/07\\\/Slovenia.jpg\",\"articleSection\":[\"Slovenia\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/tbenews.com\\\/tbe\\\/tbe12b30\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/tbe12b30\\\/\",\"url\":\"https:\\\/\\\/tbenews.com\\\/tbe\\\/tbe12b30\\\/\",\"name\":\"Slovenia - 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TBE Book","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/tbenews.com\/tbe\/tbe12b30\/","og_locale":"en_US","og_type":"article","og_title":"Slovenia - TBE Book","og_description":"TBE in Slovenia Zoran Simonovi\u0107 and Tamara Vukovi\u0107 Jankovi\u0107 ECDC risk status: endemic (data as of end 2022) History and current situation TBE is endemic in Slovenia, and the incidence rate is one of the highest in the EU. In Slovenia, TBE virus was confirmed for the first time in 1953 with isolation of the virus from a patient\u2019s blood.1 In 1955, the virus was isolated from a tick Ixodes ricinus.2 Notification of TBE cases as well as deaths due to TBE has been mandatory in Slovenia since 1977. Only cases with central nervous system involvement and laboratory confirmation are notified. Surveillance data has been collected within the communicable diseases surveillance system by the National Institute of Public Health of Slovenia (NIPH). The number of TBE reported cases in Slovenia varies every year. In the period from 1983 to 2016, the number of annually reported TBE cases was between 62 and 531 (incidence rates between 3.0 and 26.6\/100,000), which amounts to a mean of 206 cases\/year, and a mean annual incidence rate of 10.3\/100.000. In contrast to reports on increasingly higher incidence rates of TBE during the last two decades from many endemic countries, in Slovenia the reported incidence rates during the last 35 years have shown no apparent increasing or decreasing trend. Occurrence of the disease presumably fluctuates due to climatic factors influencing tick activity and population number of small forest mammals, different weather conditions during summer months in different years and other possible factors (e.g., changes in leisure activities) that have not been investigated yet. TBE virus is present in all Slovenian regions. Although some regions in Slovenia have higher incidence of TBE than others, TBE occurs throughout the country, with the most affected areas in the north and central regions (Figure 1). In some administrative units average annual TBE incidence rates exceed 45\/100,000 (Figure 2). TBE infections occur seasonally, in Slovenia mostly between April and November, with a peak in June and July.5 In the recent years an increase of the cases in the elderly has been observed. Since 1994, TBE incidence rates have been the highest in the 55\u201364 age group in most years, with males being more frequently affected than females.6 In men, the 65\u201374 age group and in women the 45\u201354 age group followed, with the second highest rates in most years. In contrast to the TBE incidence, the disease burden expressed in DALYs was higher in children aged 5\u201314 years than in adults aged 50\u201374 years.7 People who are staying in the endemic areas (temporarily or permanently) have a higher risk for TBE infection. These are mainly people working in forestry, wood and wood-processing industries and construction. The risk is also higher among farmers, if their farmlands are located near forested areas, which present a natural habitat for ticks. There have also been observations of increased TBE incidence among people who visit forests for recreational purpose or forest fruit-picking. An epidemiological study that included 1,564 cases of TBE in Slovenia showed that 82.3% of cases had a tick bite on one or multiple sites on the body. The estimated duration of tick attachment was less than 6 h in 23.5% of TBE cases. Long attachments (more than 24 h) were reported by 10% of the patients. The tick bite occurred while the TBE patients were engaged in leisure time activities (sports or camping, 32.8%), mushroom or berry picking (30.2%), or farming (23.3%). Almost two-thirds of TBE patients reported that they had practiced at least one of the recommended preventive measures, most frequently self-inspection, and least often repellent use.8 Overview of TBE in Slovenia Table 1: Virus, vector, transmission of TBE in Slovenia Viral subtypes, distribution European subtype; great heterogeneity of the viruses with geographical clustering of viruses with the same genetic characteristics.9 Reservoir animals Rodents; TBE virus antibodies were detected in 5.9% of rodent sera. Bank voles had higher rate of infection than mice.10 Infected tick species (%) In Slovenia the main vector is Ixodes ricinus and the prevalence of TBE ticks infection is 0.47%.11 Dairy product transmission Cases of alimentary TBE 2012\u20132014: 6 (4 in small outbreak in 2012).12 Table 2: TBE reporting and vaccine prevention in Slovenia Mandatory TBE reporting13,14 Reporting is mandatory. Only confirmed cases are reported formally to clinicians.Clinically diagnosed CNS infection of TBE must be confirmed by at least one of the following: the presence of specific serum IgM and IgG antibodies the presence of specific IgM antibodies in CSF IgG seroconversion to TBE virus the presence of TBE virus genome in clinical specimen isolation of TBE virus from clinical specimen. Other TBE-surveillance – Special clinical features – Available vaccines FSME-Immun and Encepur.15 Vaccination recommendations and reimbursement16,17,18,19,20 TBE vaccination was introduced in 1986. National TBE vaccination policy and recommendation implemented only for high-risk groups: since 1986, mandatory for high-risk workers (eg. foresters, hunters, farmers, gardeners, soldiers, laboratory workers) – reimbursed by employers since 1990, mandatory for students at high risk (eg. forestry, wood processing ) – reimbursed within compulsory national health insurance since 1991, recommended for all individuals living in or travelling to endemic areas including children from one year of age – paid by vaccinated individuals themselves. In 2019, the vaccination against TBE, funded by the Health Insurance Institute of Slovenia, is available to children born in 2016 and adults born in 1970. Vaccination is performed by selected personal physicians or paediatricians.Persons from these age groups who have already been vaccinated against tick-borne meningoencephalitis are eligible for the next three doses of the TBE vaccine (primary vaccination or booster).Previously unvaccinated adults 49 years old and children 3 years old, will be included in the vaccination program every year, thus gradually increasing the protection of the Slovenian population against TBE. Vaccine uptake by age group\/ risk group\/ general population In 2007, general population aged 15 years and more who reported ever to have been vaccinated against TBE was 12.4 %. No further estimations of vaccine coverage have been performed. In 2014, according to official data from National","og_url":"https:\/\/tbenews.com\/tbe\/tbe12b30\/","og_site_name":"TBE Book","article_published_time":"2017-07-24T07:44:41+00:00","article_modified_time":"2023-05-12T09:03:08+00:00","og_image":[{"width":1180,"height":250,"url":"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/07\/Slovenia.jpg","type":"image\/jpeg"}],"author":"Administrator admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Administrator admin","Est. reading time":"9 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/tbenews.com\/tbe\/tbe12b30\/#article","isPartOf":{"@id":"https:\/\/tbenews.com\/tbe\/tbe12b30\/"},"author":{"name":"Administrator admin","@id":"https:\/\/tbenews.com\/tbe\/#\/schema\/person\/dd436937ad52c89f92315a6488c1d2c7"},"headline":"Slovenia","datePublished":"2017-07-24T07:44:41+00:00","dateModified":"2023-05-12T09:03:08+00:00","mainEntityOfPage":{"@id":"https:\/\/tbenews.com\/tbe\/tbe12b30\/"},"wordCount":1612,"commentCount":0,"publisher":{"@id":"https:\/\/tbenews.com\/tbe\/#organization"},"image":{"@id":"https:\/\/tbenews.com\/tbe\/tbe12b30\/#primaryimage"},"thumbnailUrl":"https:\/\/tbenews.com\/tbe\/wp-content\/uploads\/2017\/07\/Slovenia.jpg","articleSection":["Slovenia"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/tbenews.com\/tbe\/tbe12b30\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/tbenews.com\/tbe\/tbe12b30\/","url":"https:\/\/tbenews.com\/tbe\/tbe12b30\/","name":"Slovenia - 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