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Chapter 5
TBE in adults
Johannes P. Borde and Joanna Zajkowska
Key Points:
• TBE is the most important tick-borne arbovirus disease of humans. Epidemiological data indi-
cate a trend towards an increasing severity with higher age.
• A number of possible genetic and non-genetic risk factors have been identified, which might
have an impact on the manifestation and severity of human disease.
• Different TBEV strains seem to cause differing clinical courses of disease. While the TBE-Eu
mainly causes a biphasic course, the clinical course of TBEV-FE and TBEV-Sib are mainly mo-
nophasic.
• The diagnosis of TBE is based on serological tests.
• So far there is no effective treatment of TBEV infections.
Introduction
The tick-borne encephalitis virus (TBEV) to a loss of consciousness, coma, and even
1,2
causes serious infections of the brain, the death (Figure 1). Overall, TBE is associated
myelon, and / or the meninges. Initial with a high burden of disease and often
symptoms include headache and fever. Severe disabling long-term sequelae. From an
forms of tick-borne encephalitis (TBE) progress epidemiological perspective all age groups are
Figure 1: TBE by age and gender
TBE cases by age group and gender reported in 16 EU/EFTA countries (2000-2010; n=22,378)
3
Source ECDC (TBE technical report).
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