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Chapter 9: Immunology of TBEV infection
Figure 3. Expression of chemokines, cytokines and other signalling molecules in the cerebrospinal fluid (CSF) and
is not well understood. Increased levels of CXCL1 and CXCL2 in mouse TBEV infection may explain neutrophil infiltration into the CNS. Higher levels of CXCL9 and CXCL10 in CSF compared to blood may be responsible for the selective recruitment of T cells expressing CCR5 and CXCR3. Integrin role in TBE is underex
peripheral blood, as well as their role in immune cells recruitment to the central nervous system in TBE.
Increased levels of many signalling molecules are observed in CSF and blood, however, information on their exact role in TBE
studies. 46,48,49,61,74,75,80-84
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