Page 187 - TBE_Book_V2_2019

Chapter 10: Diagnosis

Figure 1: Natural course of TBE with clinical symptoms, virus replication, and
evolution of specific anti-TBE antibodies

PCR Positivity, Amount of Virus Antibody Concentration

Days After Infection

Table 1: Detection of TBEV by RT-PCR in patient samples according to stage of
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infection
Antibody status Serum Blood CSF Brain tissue

IgM-/IgG- 30/30 (100%) 19/19 (100%) 1/10 (10%) -

IgM+/IgG- 3/13 (23%) 3/5 (60%) 0/2 (0%) -

IgM+/IgG+ 1/34 (3%) 1/6 (16%) 0/19 (0%) 1/1 (100%)

nodes, the virus then spreads to the internal infected individuals, and which includes CNS
organs via the lymph and blood (causing involvement varying in severity from
viremia) and begins to replicate within the meningeal irritation to meningoencephalo-
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reticuloendothelial system. It is during this myelitis and even death. The choice of
phase of the disease that the infected whether a specific patient should be tested
individual will often show non-specific, using an assay that directly or indirectly
influenza-like symptoms. These symptoms will detects TBEV infection therefore depends on
then begin to improve for several days before the phase of the infection of a given patient.
a second phase appears in up to 30% of

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