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Chapter 12b: TBE in Russia

Table 2: TBE reporting and vaccine prevention in Russia
Mandatory TBE reporting All TBE cases are confirmed by serological methods
(TBEV IgM ± IgG) reported in Russian Federal Service for Surveillance on Consumer
Other TBE surveillance Rights Protection and Human Wellbeing (Rospotrebnadzor)
(Source: Sanitary regulations “Prevention of tick-borne encephalitis” 3.1.3.2352-08)
1–10% – TBEV meningoencephalitis or meningo-encephalomyelitis,
35–40% – TBEV meningitis
35–40% – fever + anti-TBEV IgM or IgG increase
1–3% – chronic TBEV with no reliable data available on neurological sequelae

Special clinical features Mortality rate 1%–2%

Risk groups: permanent inhabitants and visitors of endemic areas; mainly acquired
during leisure activities, professional risk groups
(Source: Sanitary regulations “Prevention of tick-borne encephalitis” 3.1.3.2352-08)
Russian TBE vaccines:
 Klesch-E-Vac for children 0.25 mL and for adults 0.5 mL (FEDERAL STATE
BUDGETARY SCIENTIFIC INSTITUTION Chumakov Federal Scientific Center for
Research and Development of Immune and Biological Products of Russian
Academy of Sciences, Moscow)
(Source: http://chumakovs.ru/en/products)
 Tick-borne encephalitis vaccine concentrated purified inactivated adsorbed
culture dry 0,5mL (FEDERAL STATE BUDGETARY SCIENTIFIC INSTITUTION
Chumakov Federal Scientific Center for Research and Development of Immune-
and- Biological Products of Russian Academy of Sciences, Moscow)
Available vaccines
- EnceVir®Neo for children 0.25 mL (NPO Microgen, Tomsk)
- EnceVir® for adults 0.5 mL (NPO Microgen, Tomsk)
(Russian vaccines have boosters every 3 years)
European vaccines:
- Encepur adult 0.5 mL (GSK, Germany)
- Encepur baby 0.25 mL (GSK, Germany)
- FSME-IMMUN 0.5 mL (Pfizer, Austria)
- FSME-IMMUN junior 0.25 mL (Pfizer, Austria)
(Source: http://www.microgen.ru/en/)
National Immunization Calendar for epidemic indications (Order of the Ministry of
Health of the Russian Federation №125n, part 2): endemic regions have the right to
implement local immunization program (RIP) with vaccination rates determined by
financial conditions in the region.
(universal vaccination or vaccination of risk groups only – i.e. infants and elderly)
Vaccination
recommendations and Vaccination is indicated for:
reimbursement
 persons living in endemic areas (all ages)
 persons with occupational risk (forest workers, etc.)
 persons traveling to endemic areas
(Source: Sanitary regulations “Prevention of tick-borne encephalitis” 3.1.3.2352-08; Ministry
of Health Order #125-n part 2 “National Immunization Calendar for epidemic indications”)
Name, address/ Irkutsk Anti-Plague Research Institute of Rospotrebnadzor,
website of TBE NRC Irkutsk, Russian Federation (http://irknipchi.ru)

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