Page 424 - TBE_Book_V2_2019
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Chapter 12b: TBE in Switzerland/Liechtenstein


           Table 2: TBE reporting and vaccine prevention in  Switzerland
                           Notifiable disease since 1988
           Mandatory TBE   Tick bites and Lyme borreliosis have been reported via a sentinel group
           reporting                                                            5,9
                           (general practitioners and pediatricians in the entire country) since 2008
                           Case        Laboratory criteria   Clinical criteria
                           classification
                           Not a case   Positive IgM serology   No ILI & no neurological symptoms
                                           Positive IgM      ILI or non-specific neurological signs &
                           Possible case   a)
                                           serology          symptoms
                                           Positive IgM +
                                       b)   positive IgG     Any
                                           serology*
                      5
           Categorization    Probable   a)   Positive IgM    Meningitis, meningoencephalitis,
                           case            serology          encephalomyelitis or pareses
                                           Positive IgM +    ILI or non-specific neurological signs or
                                       b)   positive IgG     symptoms
                                           serology*
                                           Positive IgM +
                           Confirmed                         Meningitis, meningoencephalitis,
                                       a)   positive IgG
                           case                              encephalomyelitis, or pareses
                                           serology*
                                           TBE-RNA detection   Meningitis, meningoencephalitis,
                                       b)
                                           by PCR            encephalomyelitis, or pareses
           IgG, immunoglobulin; IgG, immunoglobulin; ILI, influenza-like illness; PCR, polymerase chain reaction
           *Or anti-TBE IgG serum antibody seroconversion or ≥4-fold rise in anti-TBE IgG serum antibodies
           Special clinical   No Swiss data
           features
                           % with sequelae: 25%; mortality: 1%
                                  ®
                           Encepur N  (Novartis/GSK)
           Available       FSME-Immun  (Baxter/Pfizer)
                                    ®
                 10
           vaccines
                           Number of doses sold: not available
           Vaccination
           recommendations   Recommendations and reimbursement for vaccination in 2006
           and
                      10
           reimbursement
                           Average national vaccination uptake (3 doses), 2014-16:
           Vaccine uptake by   8 years old: 22-31%
           age group/risk   16 years old: 33-45%
           group/general   High-risk area (canton of Thurgau):
                   11
           population      8 years old: 40-53%
                           16 years old: 64-75%
                           National Reference Center for Tick-borne Diseases, SPIEZ LABORATORY is a division of
           Name, address/  the Federal Office for Civil Protection
           website of TBE   LABOR SPIEZ
           NRC             Austrasse
                           3700 SPIEZ - Switzerland
                           https://www.labor-spiez.ch/de/die/bio/dediebionrz.htm
                           nrzk@babs.admin.ch



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