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Chapter 12b



                          TBE in  Switzerland



                            and Liechtenstein



                 Daniel Desgrandchamps and Klara M. Posfay-Barbe



          History and Current Situation

          The  first  serological  reports  of  tick-borne   for the cantons of Geneva and Ticino – as an
          encephalitis (TBE) in Switzerland date back to   at-risk area in which TBE vaccination is recom-
          the early 1970s [T. Krech. Dissertation, Univer-  mended  for  all  individuals  with  possible
                                                                                           2
          sity  of  Berne,  1980].  Surveillance  started  in   exposure  (both  as  residents  or  as  visitors),
          1984, and TBE became a notifiable disease in   see Figure 3c.
          1988. Most cases are reported between April
          and  October  with  a  tick  bite  exposure  below   Currently, vaccination is generally recommend
                                     1,2
          an altitude of 1500-2000 meters.            -ed  and  reimbursed  by  health  insurance  for
                                                      individuals older than 6 years of age living in
          Tick-borne  encephalitis  virus  (TBEV)  has  not   or visiting endemic regions. In children aged 1-
          been identified in ticks from all regions of the   5  years,  the  indication  shall  be  based  on
          country.  This  explains  why  human  cases  are   individual  considerations.  Unlike  in  other
          mainly found in endemic but not in all regions.   countries  and  in  contrast  to  the  label,  a
          Most  cases  occur  in  the  northeast  of  the   booster dose is recommended every 10 years
                                                          3
          country,  but  in  recent  years,  new  endemic   only.
          regions have been detected in western (Vaud)
          and south-western Switzerland (Valais), which   Between 2000 and 2018, the Federal Office of
          suggests that TBE has become endemic almost   Public Health has received between 52 annual
          in the entire country.                      reports  of  TBE  cases  in  2002  (incidence
                                                      0.7/100,000),  and  376  cases  in  2018
          In  2013,  a  procedure  allowing  for  the   (incidence 4.4/100,000). The number of cases
          definition  of  regions  with  a  local  TBE   fluctuated considerably from year to year; the
          vaccination recommendation had been adopt-  highest  average  value  was  24.8/100,000
                                           3
          ed  for  Switzerland  and  Liechtenstein.   Data   (2018)  in  the  canton  of  Uri  in  central
          from  cases  notified  over  the  last  10  years   Switzerland. So far, only 10 out of 26 cantons
          (“high risk areas”, Fig. 3a) were combined with   plus  Liechtenstein  have  notified  at  least  1
          data from the historical map of Swiss endemic   patient every year.
                                                                     4
          regions  and  “natural  clusters”.  The  resulting
          Swiss  map  was  used  until  2018  for  the   As  elsewhere  in  Europe,  the  proportion  of
          definition of regions where TBE vaccination is   ‘mild cases’ is lower and the number of more
          recommended for exposed people (Figure 3b).   serious  cases  higher  with  increasing  age.
                                                      However,  more  serious  disease  pictures  like
          However, in view of the increasing numbers of   meningoencephalitis have also been reported
          reported TBE cases in recent years, Swiss and   in children below the age of 6 years over the
          Liechtenstein  health  authorities  decided  in   last  years  (E.  Altpeter,  FOPH,  personal
          2019 to consider the entire countries – except   communication).  Less  than  half  (45%)  of



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