Page 445 - TBE_Book_V2_2019

Chapter 14: Prevention

Sen Tai Bao Changchun Institute of Biological Products TBEV-Fe Senzhang NK PHKC NK Al(OH) 3 NK HSA NK NK 21 months (temperature NK)

Dry -lyophilized TBE- Moscow scientific institution Chumakov TBEV-Fe Sofjin PCEC PCEC titer >1:128 Al(OH) 3 no Sucrose, HSA 0.5 mL Dry in ampoules 36 months (2°-8°C)

TBEV-Fe Strain 205 EnceVir® -0,6-3,0 µg/ EnceVir®Neo -0,3-1.5
EnceVir® and EnceVir®Neo NPO PCEC PCEC µg Al(OH) 3 no Sucrose, HSA 0.5 mL/0.25 mL liquid in ampoules 24 months (2°-8°C)

TBE-Moscow / Klesch-E-Vac Federal state scientific institution Chumakov TBEV-Fe Sofjin PCEC PCEC 0.5-0.75 µg (titer > 1:128) Al(OH) 3 no Sucrose, HSA 0.5 mL/0.25 mL liquid in ampoules 24 months (2°-8°C) Abbreviations: HSA: Human Serum Albumin; PCEC: Primary Chicken Embryonic Cells; PHKC: primary hamster kidney cells; Al(OH) 3: Alumin
Table 1: Basic characteristics of all licensed TBE vaccines

Encepur ® GSK TBEV-Eu K23 PCEC PCEC 1.5 µg/0.75 µg children Al(OH) 3 no Sucrose 0.5 mL/0.25 mL liquid prefilled syringe 24 months (2°-8°C)

FSME-IMMUN ® Pfizer TBEV-Eu Neudörfl PCEC PCEC 2.4 µg/1.2 µg children Al(OH) 3 no HSA 0.5 mL/0.25 mL liquid prefilled syringe 30 months (2°-8°C) NK: Not known

Vaccine name/ Manufacturer Antigen Strain Passages Production Amount of antigen Excipients Adjuvant Preservative Stabilizer Presentation Formulation Packaging Shelf-life

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