Page 323 - TBE_Book_V2_2019

Chapter 12b: TBE in Kazakhstan

Table 2: TBE reporting and vaccine prevention in Kazakhstan
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Any healthcare worker who has any reason to suspect that the patient has TBE.

Case of tick-borne encephalitis is if one of the following:
1. isolation of TBEV from blood or cerebrospinal fluid;
2. detection of TBEV RNA in PCR;
3. detection of IgM to TBEV by ELISA in serum or cerebrospinal fluid;
4. increasing titer of IgG antibodies to TBEV in ELISA

Probable case of TBE is acute severe disease, accompanied by high fever, severe
intoxication, and a syndrome of meningitis or meningoencephalitis, characterized
Mandatory TBE reporting by at least four of the following:
1) hyperemia and puffiness of face;
2) lethargy or agitation;
3) headache;
4) nausea and vomiting;
5) meningeal symptoms (stiff neck, Kernig, the children Brudzinsky) and one of
the following: tick bite; contact with a tick; epidemiologic link with a confirmed
case

Possible cases - the definition of a suspected (possible) case in the TBE
classification is not being used

Other TBE surveillance It’s not clear
Special clinical features Bi-phasic disease? Usually no Risk groups? Local population in endemic zones
Vaccine tick-borne encephalitis cultural concentrated purified inactivated sorbate
‘EnceVir’ (ЭнцеВир ®) Russia.

Suspension for intramuscular injection. 1 dose (0.5 mL) in a vial

One dose (0.5 mL) contains inactivated antigen of tick-borne encephalitis virus
(TBE) in ELISA titer of at least 1:128 (active component).

Available vaccines The course of vaccination consists of two injections with an interval of 1-7
months. Course of vaccination (two vaccinations) can be carried out throughout
the year, including during the summer period (season) but not later than two
weeks prior to the visit of TBE endemic zone. The optimal interval between the
first and second vaccinations - 5-7 months (autumn-spring).

If necessary, emergency prevention, including, at the beginning of vaccinations in
the summer, the interval between vaccinations may be reduced to 14 days.
Manufacturer scientific practical association: ‘Microgen’, Russia, Tomsk.
Vaccination
recommendations and Give year when recommendations / reimbursement started, year of changes etc.
reimbursement
Vaccine uptake by age Medical organizations hold preventive, routine immunization against tick-borne
group/risk group/general
population encephalitis professionally threatened contingents (risk group).
Scientific practical center for sanitary and epidemiological expertise and
Name, address/website of
TBE NRC monitoring (SPC SEEM), Parasitology Department #84, Auezov street,
Almaty, 050008

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