Page 48 - TBE_Book_V2_2019

Chapter 2b: The molecular and antigenic structure of TBEV

Figure 1: Structural organization of flaviviruses

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(A,B) Ribbon diagrams of the TBEV sE dimer [PDB code: 1SVB, (1)] and full-length E dimer [PDB code: 5O6A, ]. (A)
Top view. (B) Side view. Color code E: domain I (DI), red; domain II (DII), yellow; domain III (DIII), blue; fusion
loop (FL), orange; stem, green; membrane anchor, grey.
(C,D) Schematic representations of immature (C) and mature (D) virus particles.
(E,F) Electron cryo-microscopy structures of dengue virus serotype 1 particles. (E) Immature virion [PDB code:
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4B03, ]. (F) Mature virion [PDB code: 4CCT, (21)]. The prM proteins are shown in purple, and the E proteins
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in gray. (G) Electron cryo-microscopy structure of TBEV [PDB code: 5O6A, ], with individual domains of E
colored as in A to D. One raft consisting of 3 parallel E dimers is encircled in white.
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Panels A, B, E and F were prepared with PyMOL (Schrödinger LLC), panel G with UCSF Chimera [ , http://
www.rbvi.ucsf.edu/chimera/].

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DIII) that are connected to each other and the (the dengue virus E protein) was published.
membrane-associated part of the protein by Meanwhile, atomic resolution structures of E
flexible linker regions. It took eight additional proteins are available for several of the most
years until another flavivirus E protein structure important human pathogenic flaviviruses,

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