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Chapter 2b: The molecular and antigenic structure of TBEV
(A) Ribbon diagrams of E monomers in their pre- and post-fusion conformations, revealing the relocation of domain III (indicated by a blue arrow in the pre-
Figure 3: Post-fusion structure of E and fusion mechanism
fusion conformation). (B) Ribbon diagram of the trimeric post-fusion structure of TBEV sE [PDB code: 1URZ, 87 ]. (C) Schematic of steps involved in flavivirus membrane fusion. Panel I: Metastable E dimers at the viral surface. Panel II: Low-pH-induced dimer dissociation, exposure of the FL and interaction with the endosomal m
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